Browsing Departament de Patologia i Terapèutica Experimental by Subject "616.8"
Now showing items 1-11 of 11
Canales de calcio y dolor: Investigación del mecanismo de acción de la pregabalina sobre la neurotransmisión
Martínez San Segundo, Pablo (Date of defense: 2019-04-26)
Los gabapentinoides son una familia de fármacos que se unen con gran afinidad a la subunidad α2δ-1 de los canales de calcio voltaje-dependientes (VGCCs). Fármacos de esta familia como la pregabalina o la gabapentina se ...
CB(1), A(2A) and D(2) receptors balance as a target against psychotic-like symptoms associated to Alzheimer’s disease and cannabis abuse
Gómez Acero, Laura (Date of defense: 2024-10-31)
[eng] Psychosis is a mental health problem characterized by a loss of contact with reality, which is considered the defining feature of schizophrenia spectrum disorders. However, psychotic symptoms may occur in other medical ...
Factors sèrics en l’Esclerosi Lateral Amiotròfica. Modulació del receptor de glutamat de tipus NMDA GluN1/GluN2A
Teixidó Viyuela, Laura (Date of defense: 2011-02-18)
L’Esclerosi Lateral Amiotròfica (ELA o ALS) és una malaltia neuromuscular caracteritzada per la degeneració selectiva de les motoneurones (MN) superiors e inferiors del còrtex motor, el tronc de l’encèfal i la medul•la ...
Identification of a risk transcriptome and proteome in Parkinson’s disease, Dementia with Lewy bodies and rapidly progressive Dementia with Lewy bodies
Garcia Esparcia, Paula (Date of defense: 2016-12-02)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by movement impairment, or parkinsonism, for which there is still no cure. The manifest clinical signs result from neuronal loss of more ...
Modeling neuro-immune interaction in Parkinson’s disease using an iPSC-based autologous in vitro system
Baruffi, Valentina (Date of defense: 2024-12-20)
[eng] Parkinson’s disease (PD) is a chronic, incurable, progressive neurodegenerative disorder pathologically characterized by intracellular aggregates of α-synuclein (α-syn) forming Lewy bodies (LBs) and the loss of ...
Natural cannabinoids against Alzheimer’s disease: a role in glutamatergic regulation
Sánchez Fernández, Nuria (Date of defense: 2024-12-05)
[eng] Alzheimer's disease (AD), characterized by the loss of memory and other cognitive abilities, is the predominant form of dementia. Given the impact it has on individuals, affected families and health systems, it is ...
Novel pharmacological strategies for neurological conditions involving glutamate and adenosine
Sarasola Telleria, Laura I. (Date of defense: 2025-05-28)
[eng] Neuropsychiatric disorders such as schizophrenia and bipolar disorder present alterations in dopaminergic and glutamatergic neurotransmission, which has led to the development of therapeutic strategies targeting these ...
Novel regulation of AMPA receptor function by interacting protein CPT1C
Yefimenko Nosova, Natalia (Date of defense: 2016-06-17)
AMPA receptors (AMPARs) are responsible for the 90% of synaptic transmission and are involved in plasticity, developmental and neurological processes. Their function depends on the proteins interacting with the AMPAR ...
Papel de la endocitosis mediada por clatrina y de la proteína SPARC sobre la plasticidad sináptica
López Murcia, Francisco José (Date of defense: 2015-04-07)
Desde que se establecen las sinapsis hasta que son plenamente maduras, experimentan diversos cambios. En el terminal presináptico, a nivel morfológico se produce un rellenado progresivo del número de vesículas sinápticas ...
Synaptic transmission in autaptic circuits: presynaptic homeostatic plasticity and microtubule dynamics
Velasco Domínguez, Cecilia (Date of defense: 2022-04-22)
Synapses are the contact sites where the transfer of information from the presynaptic to the postsynaptic site occurs. Correct processing of information requires that synapses continuously adapt their properties to an ...
Vías de señalización en enfermedades priónicas
Rodríguez Fernández, Agustí (Date of defense: 2007-10-04)
Las enfermedades priónicas, también conocidas como EETs (Encefalopatías Espongiformes Transmisibles), son un grupo de enfermedades neurodegenerativas fatales que, debido a su transmisibilidad potencial han tenido un gran ...


