Now showing items 41-60 of 107

    Estudios funcionales y estructurales en quinasas dependientes de ADP relacionadas con el metabolismo de glucosa en Archaea 

    Herrera Morandé, Alejandra Margarita (Date of defense: 2015-10-09)

    En algunos organismos Archaeas, la vía glicolítica presenta modificaciones entre las que destaca las enzimas quinasas que fosforilan glucosa y fructosa 6-fosfato utilizando ADP en vez de ATP como dador de grupo fosforilo. ...

    Estudios sobre la toxocarosis humana en Barcelona: puesta a punto y ensayo de una técnica diagnóstica 

    Riera Lizandra, Ma. Cristina (Date of defense: 1991-01-01)

    La tesis ha constado de dos partes: 1) Puesta a punto de una técnica EIA para la detección de anticuerpos anti-toxocara y 2) Estudio seroepidemiológico de la población hospitalaria en Barcelona. Se ha utilizado un antígeno ...

    Evaluation of (eco)toxicity and biodegradability of short aliphatic protic ionic liquids 

    Peric, Brezana (Date of defense: 2014-12-17)

    Ionic liquids (ILs) are a fairly new and very promising group of compounds. They are often considered as environmentally benign substitutes for traditional volatile organic solvents due to their attractive properties and ...

    Evolució i caràcter hereditari del ritme d'activitat motora de la rata 

    Cambras Riu, Trinitat (Date of defense: 1986-01-01)

    Aquest treball està basat en un experiment de més d'un any i mig d'observacions diàries, dissenyat per tal d'estudiar alhora dos objectius principals: l'un ha estat l'estudi de l'evolució del patró del ritme circadiari ...

    Exploration of sulfated polysaccharides as antimalarials and as targeting molecules for nanovector-mediated drug delivery to Plasmodium-infected cells 

    Marques, Joana (Date of defense: 2015-12-14)

    Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium spp. ...

    Exploring structure-function relationship of the mitochondrial DNA packaging protein Abf2p and its dialogue with the DNA 

    Chakraborty, Arka (Date of defense: 2016-07-08)

    Mitochondria are intracellular double-membrane bound organelles in eukaryotic cells that act as the major suppliers of adenosine triphosphate (ATP). They possess their own DNA (mtDNA) that codes for components of the ...

    Functional analysis of EXD2 in mitochondrial homeostasis 

    Faria da Silva, Joana Raquel (Date of defense: 2017-03-24)

    One of the most fundamental events in the history of life is the origin of mitochondria. It was firstly proposed by Ivan Wallin, and later popularized by Lynn Margulis, as part of the endosymbiotic theory, that mitochondria ...

    Genome-wide transposon analyses: annotation, movement and impact on plant function and evolution 

    Hénaff, Elizabeth Marie (Date of defense: 2013-06-20)

    The diversity of life forms around us is astounding: a walk in the woods, or even down the street, shows us organisms of different morphologies: two legs, four legs, wings; different capacity of interaction with our ...

    Glucosa 1,6-bisfosfat i glucosa 1,6-bisfosfat fosfatasa en el teixit muscular de mamífer 

    Bassols Teixidó, Anna (Date of defense: 1986-01-01)

    En el Departament de Bioquímica de la Facultat de Medicina s'està portant a terme, des de fa un temps, una línia d'investigació basada en l'estudi del metabolisme del 2,3-bisfosfoglicerat, el cofactor de la ...

    hAGT inhibitors as chemotherapy enhancers 

    Tintoré Gazulla, Maria (Date of defense: 2015-07-01)

    The O6-alkylguanine DNA alkyltransferase (hAGT or MGMT) is a DNA repair protein in charge of removing alkyl adducts from the O6 position of guanines, blocking their cytotoxic effects and playing an important role as a ...

    Hallmarks of Dermal Fibroblast Aging 

    Salzer, Marion Claudia (Date of defense: 2019-04-10)

    Aging is accompanied by cellular, extracellular and systemic changes that impair tissue function. Stromal alterations, such as degeneration of the extracellular matrix, are thought to contribute to organ deterioration in ...

    Human Immunodeficiency Virus infection, asymptomatic atherosclerosis, and inflammation: A candidate gene study 

    Ibáñez Lladó, Laura (Date of defense: 2014-04-07)

    Acquired Immunodeficiency Syndrome (AIDS) was identified more than 30 years ago. The challenges for the clinicians and Human Immunodeficiency Virus (HIV)-infected individuals have changed over the years. Nowadays, viral ...

    Identificació i estudi funcional de nous gens supressors tumorals implicats en càncer de pulmó 

    Bonastre Llort, Ester (Date of defense: 2014-10-30)

    El càncer de pulmó afecta 1,6 milions de persones a tot el món, i és la primera causa de mort per càncer. El promig de l’índex de supervivència als 5 anys per tots els càncers està al voltant del 50%, mentre que en el cas ...

    Identificación de posibles factores de Myzus persicae implicados en la transmisión del virus del grabado del tabaco (TEV) y estrategias para interferir su expresión 

    Urizarna España, María (Date of defense: 2013-04-26)

    En esta tesis se aborda la identificación de factores del pulgón Myzus persicae que podrían participar en el proceso de transmisión del potyvirus del grabado del tabaco, Tobacco etch virus (TEV), y se explora la posibilidad ...

    Identification of mechanisms of acquired resistance to taxanes in triple negative breast cancer using patient-derived xenografts: a step closer to clinics 

    Gómez Miragaya, Jorge (Date of defense: 2018-04-27)

    Chemotherapy is a general treatment for most breast tumors and depending on breast cancer subtype combination with targeted anti-hormonal or anti-HER2 therapy is conducted. Taxane-based regimens constitute the most common ...

    Identification of novel therapeutic targets and tumor suppressor genes in colon cancer using genome-wide high‐throughput approaches 

    Bazzocco, Sarah (Date of defense: 2016-01-27)

    Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of tumor suppressor genes ...

    Implicación de LRP5 en la enfermedad cardiovascular 

    Romero Sandoval, July Carolina (Date of defense: 2014-12-01)

    Atherosclerosis is an inflammatory process characterized by the accumulation of lipids and fibrous elements in large arteries. It is the main underlying pathological process leading to heart attack and stroke. Low-densit ...

    Implicación del Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) en el remodelado vascular y cardiaco 

    Revuelta López, Elena (Date of defense: 2015-12-01)

    La dislipemia y la hipoxia tienen un impacto directo en el remodelado vascular y cardiaco. La isquemia cardiaca produce una disfunción generalizada del corazón caracterizada por alteraciones en el metabolismo celular y ...

    Insulators: estructura y funciones 

    Fresán Salvo, Ujué (Date of defense: 2016-05-11)

    Los insulators son complejos de DNA y proteínas, cuya función no solo consiste en impedir la comunicación enhancer-promotor y/o bloquear la expansión del silenciamiento de la heterocromatina como clásicamente se habían ...

    The Iron Regulatory Protein/Iron Responsive Element (IRP/IRE) system: functional studies of new target mRNAs and pathological implications for novel IRE mutations 

    Luscieti, Sara (Date of defense: 2016-11-22)

    Iron is an essential micronutrient required for many cellular reactions and a tight regulation of its metabolism is therefore crucial for health. Cellular iron homeostasis relies on the coordination of iron uptake, storage ...