Browsing Facultat de Farmàcia by Title

Structural Insights into Substrate Binding and Regulation of E3 Ubiquitin Ligases in the Nedd4 Family using NMR Spectroscopy

Escobedo Pascual, Albert (Date of defense: 2014-11-06)

Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels proteins for a variety ...

Structural Modeling and Characterization of Protein Interactions of Biomedical Interest: The Challenge of Molecular Flexibility

Pallara, Chiara (Date of defense: 2016-02-04)

Proteins are large biomolecules that play essential functional and structural roles within cells and that typically act through their interaction with other proteins and biomolecules, forming highly specific functional ...

Structure, dynamics and interactions of the N-terminal domain of the androgen receptor

De Mol, Eva (Date of defense: 2014-06-26)

Prostate cancer (PCa) is the second most common cancer in men after lung cancer. Around 1.1 million men worldwide were diagnosed with PCa in 2012. PCa depends essentially on androgen stimulation for growth and cell survival. ...

Supramolecular Strategies to Control the Assembly of Organic-Based Materials

Riba Moliner, Marta (Date of defense: 2015-12-11)

The focus of this thesis is the use of supramolecular chemistry to functionalize polymers to obtain organic-based materials with a control of their structure and properties. The non-covalent functionalization of polymers ...

The epigenetic regulation of cell cycle and chromatin dynamic by sirtuins

Martínez Redondo, Paloma (Date of defense: 2014-06-25)

The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded in the DNA. The ...

The role of p19 C-H-Ras protein in metastasis and proliferative pathways

García Cruz, Roseli Marlen (Date of defense: 2013-10-03)

H-Ras es un protooncogen que codifica para dos proteínas por splicing alternativo la p19 y la p21 (1,2). La p21 presenta mayor tamaño y se localiza en la membrana en donde realiza la función de GTPasa que activa múltiples ...

The role of the Tousled Like Kinases in genome stability and mammalian development

González Burón, Helena (Date of defense: 2014-03-19)

The human Tousled-like kinases 1 and 2 (TLKs) are predicted serine/threonine kinases that show maximal activity in S phase and are transiently inhibited by the DNA damage response (DDR). Both TLKs interact with and ...

ToxT promoter recognition by ToxR transcription factor, a co-activator within the Vibrio cholerae virulence cascade

Pieretti, Simone (Date of defense: 2016-06-02)

Cholera is an acute diarrheal infection caused by the bacterium Vibrio cholerae. An estimated 2.9 million of cases and about 100000 cholera deaths occur annually all over the world. Upon ingestion of the V. cholerae, the ...

Using Phosphorodiamidate Morpholino Oligomers (PMOs) to characterize the role of neurofibromin in cell physiology

Biayna Rodríguez, Josep (Date of defense: 2016-01-22)

The role of neurofibromin, the product of the Neurofibromatosis Type 1 (NF1) gene, in cell physiology is still not well understood. Considering the different traits associated to NF1 it is clear that neurofibromin participates ...