Facultat de Farmàcia: Recent submissions
Now showing items 21-40 of 107
CPEB2 in mammary gland homeostasis and breast cancer
The mammary gland develops postnatally and is remodeled, during each estrous cycle and pregnancy, through very dynamic expansions and involutions of its polarized epithelial tree. Moreover, the mammary gland is hierarchically ...
Identification of mechanisms of acquired resistance to taxanes in triple negative breast cancer using patient-derived xenografts: a step closer to clinics
Chemotherapy is a general treatment for most breast tumors and depending on breast cancer subtype combination with targeted anti-hormonal or anti-HER2 therapy is conducted. Taxane-based regimens constitute the most common ...
New targets in tumor angiogenesis to block tumor re-growth and therapeutic resistance
Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these agents mainly serve ...
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Tissue-Specific Stress
The correct timing of adult stem cell function is essential for tissue homeostasis. Our group was among the first to show that circadian rhythms segregate important stem cell functions along the day. For instance, in mouse ...
Role of p38 MAPK in breast cancer
In normal epithelial cells, p38α has a well-established role as a tumor suppressor. However, recent reports have illustrated pro-tumorigenic functions for the p38α pathway by promoting tumor cell survival and proliferation. ...
Functional analysis of EXD2 in mitochondrial homeostasis
One of the most fundamental events in the history of life is the origin of mitochondria. It was firstly proposed by Ivan Wallin, and later popularized by Lynn Margulis, as part of the endosymbiotic theory, that mitochondria ...
Microalgae as a new source of chitosans
Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the ...
Protein-protein docking for interactomic studies and its aplication to personalized medicine
Proteins are the embodiment of the message encoded in the genes and they act as the building blocks and effector part of the cell. From gene regulation to cell signalling, as well as cell recognition and movement, ...
Connecting centrosomes, cilia and the DNA damage response
The suppression of genome instability by the DNA damage response (DDR) is critical for preventing human diseases characterized by developmental defects, infertility and in some cases, elevated cancer predisposition. After ...
Biophysical study of the aggregation of the androgen receptor protein in spinal bulbar muscular atrophy
Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the coding region for the ...
Delivery of SN-38 in pediatric solid tumors
A new combined microdialysis – tumor homogenate method for the determination of compartmental (vascular, extra- and intracellular) SN-38 distribution in patient-derived xenografts (PDX) generated from pediatric solid tumors ...
The Multiple Tasks Endured by PI3K during neural tube development
Development of the spinal cord involves coordination between exposure to localized extracellular signals and controlled activation of intracellular signaling pathways. This way, neuroepithelial cells firstly proliferate ...
The Iron Regulatory Protein/Iron Responsive Element (IRP/IRE) system: functional studies of new target mRNAs and pathological implications for novel IRE mutations
Iron is an essential micronutrient required for many cellular reactions and a tight regulation of its metabolism is therefore crucial for health. Cellular iron homeostasis relies on the coordination of iron uptake, storage ...
Novel roles for the mitotic kinase Nek7 in hippocampal neurons
The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such as their stability, ...
Effects of the mediterranean diet and virgin olive oil on the function of high-density lipoproteins and the atherogenicity of low-density lipoproteins in humans
Cardiovascular diseases are the main cause of death worldwide and a relevant source of economic cost and physical disability. The Mediterranean Diet, associated with a high intake of virgin olive oil, has been shown to be ...
Molecular mechanisms involved in the immunomodulation induced by LIF in cancer
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Dissecting the function of γTuRC subunits in microtubule nucleation and organization
The depletion of MZT1 in human cells causes severe mitotic spindle defects. Depleted cells lack centrosomal γ-tubulin and arrest in mitosis with a monopolar spindle configuration. Similarly, double deletion mutants of the ...
Development and optimization of high-performance computational tools for protein-protein docking
Computing has pushed a paradigm shift in many disciplines, including structural biology and chemistry. This change has been mainly driven by the increase in performance of computers, the capacity of dealing with huge amounts ...
Development of a biomimetic mechanical stimulation system to improve the maturation of human iPS-derived myocardial grafts
La ingeniería tisular cardíaca ha evolucionado rápidamente en los últimos años, desde los primeros ensayos con diferentes especies animales hasta la producción de la primera generación de tejidos cardíacos humanos que ...
Exploring structure-function relationship of the mitochondrial DNA packaging protein Abf2p and its dialogue with the DNA
Mitochondria are intracellular double-membrane bound organelles in eukaryotic cells that act as the major suppliers of adenosine triphosphate (ATP). They possess their own DNA (mtDNA) that codes for components of the ...
