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Functional analysis of Drosophila melanogaster linker histone dH1
We did functional characterisation of Drosophila melanogaster linker histone, dH1. In the mutant state for this protein, we observed structural changes in polytene chromosomes chromocenter and nucleoli of mutant larvae. ...
Functional analysis of EXD2 in mitochondrial homeostasis
One of the most fundamental events in the history of life is the origin of mitochondria. It was firstly proposed by Ivan Wallin, and later popularized by Lynn Margulis, as part of the endosymbiotic theory, that mitochondria ...
Functional analysis of JmjC+N histone demethylases in Drosophila melanogaster
La metilació de les lisines de les histones està implicada en les funcions associades a la cromatina, com l’expressió gènica o la formació d’heterocromatina. És una modificació covalent afegida per metiltransferases ...
Functional analysis of Mobile toolkits in high-resolution Middle Paleolithic contexts: Abric Romaní (Barcelona, Spain) and Nahal Mahanayeem Outlet (NMO, Israel)
Aquesta tesi doctoral es centra en una anàlisi funcional exhaustiva d'eines lítiques mòbils en dos jaciments del Paleolític Mitjà: Abric Romaní a Barcelona, Espanya, i Nahal Mahanayeem Outlet (NMO) a Israel. L'estudi ...
Functional analysis of position effects of inversion 2j in Drosophila buzzatii: gene CG13617 silencing and its adpative significance
És sabut de fa molt temps que les inversions cromosòmiques son mantenides per selecció natural a les poblacions de Drosophila. No obstant, els mecanismes moleculars que generen aquest valor adaptatiu encara no es coneixen. ...
Functional analysis of the extraproteasomal ubiquitin receptor Dsk2/UBQLN in Drosophila and human cells
Dsk2/UBQLN is a conserved extraproteasomal ubiquitin receptor that has been widely described as a protein involved in the ubiquitin proteasome pathway. In Drosophila, this protein has been recently reported in a non-proteolitic ...
Functional Analysis of the Lithic Assemblages from the Middle and Upper Paleolithic sites of Khorramabad Valley (Western Iran), with special reference to Kaldar Cave
Aquesta tesi se centra en l'estudi funcional de conjunts de Paleolític mitjà i superior de la Vall de Khorramabad (Iran occidental), amb especial atenció a la cova de Kaldar. S'emmarca en un projecte de recerca multidisciplinària ...
Functional analysis of variant proteins in Plasmodium vivax: Implications in pathology
P. vivax is the most widespread malaria, it accounts for 25-40% of the global disease burden and it is estimated that causes from 132 to 391 million clinical cases each year. It is amply accepted that P. vivax do not ...
Functional and evolutionary implications of single nucleotide substitutions in human microRNAs across primates
MicroRNAs (miRNAs) are major contributors to phenotypic diversity and have a demonstrated role in evolution. We performed an analysis on how miRNA nucleotide substitutions may have contributed to human divergence from their ...
Functional and molecular characterization of maize open stomata 1 protein kinase
Plant growth and productivity are compromised by environmental stresses such as pathogens, extreme temperatures, drought and high salinity. Being sessile organisms, plants had to develop different physiologic and biochemical ...
Functional and Phylogenetic Diversity of Amphibians in the Brazilian Atlantic Forest: Implications for a Systematic Conservation Planning
Biodiversity patterns are results of ecological and evolutionary processes. Understanding the forces shaping biodiversity patterns help to predict the responses of ecosystems to environmental change. Considering the role ...
Functional and structural analyses of the terminal organelle of Mycoplasma genitalium
Mycoplamsa genitalium es un patógeno humano causante de uretritis no gonocócica y no causada por clamidias en hombres y de enfermedad pélvica inflamatoria y cervicitis. Los micoplasmas, además de ser muy interesantes para ...
Functional and structural studies of AKR1B15 and AKR1B16: Two novel additions to human and mouse aldo-keto reductase superfamily
La superfamília de les aldo-ceto reductases (AKR) comprèn un gran nombre de proteïnes monomèriques de localització citosòlica d’un un pes molecular d'aproximadament 36 kDa. Les AKRs tenen un plegament proteic comú evolutivament ...
Functional characterization in vivo of essential Saccharomyces cerevisiae's hydrophilin for desiccation tolerance
La sobre expressió de les hidrofilines STF2 i SIP18 en soques de laboratori, tenen un efecte positiu en la tolerància a la deshidratació i rehidratació. A més, la sobre expressió de SIP18 en quatre soques comercials de ...
Functional characterization of AWR affector proteins from the phytopathogen "R. solanacearum" (Caracterització funcional de les proteïnes efectores AWR del fitopatogen "R. solanacearum")
"R. solanacearum" is a devastating bacterial pathogen that infects "Solanaceae" spp. such as tomato, eggplant or banana. A functional T3SS is required for virulence and more than 70 putative effectors have been described, ...
Functional characterization of REVEILLE 8 and NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED interaction in the diurnal regulation of anthocyanin biosynthesis
El reloj circadiano es un mecanismo celular endógeno presente en prácticamente todos los organismos. Una función clave del reloj es la sincronización del metabolismo, fisiología y desarrollo con los cambios medioambientales ...
Functional characterization of single amino acid variants
Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common kind of variation ...
Functional characterization of the CD300e leukocyte receptor
The focus of this work was to functionally characterize the CD300e receptor expressed in human monocytes and myeloid dendritic cells and investigate the implications that receptor engagement has on their biology. We provide ...
Functional characterization of the connection between the circadian clock and the DNA damage and repair response in Arabidopsis thaliana
En la mayoría de los organismos estudiados, el reloj circadiano mantiene ritmos en fisiología, metabolismo y desarrollo en sintonía con los cambios medioambientales que suceden durante los ciclos diurnos y nocturnos. En ...
Functional connectivity anomalies in the neural networks mediating motivated behavior : assessong obsessive-compulsive disorder , chronic cannabis use, Prader-Willi syndrome and Down syndrome
Compulsive, impulsive, and addictive disorders display some behavioral commonalities associated with a dysfunction in the regulation of motivated, goal-directed behavior. Relevant to motivated behavior, there is a set of ...
