Universitat de Barcelona
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LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Glucocorticoids are frequently included in the chemotherapy regimens administered to patients with CLL because they are potent immunosuppressant agents and because they are able to induce apoptosis in CLL cells. Although ...
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent manner in ...
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
[cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...
We propose a molecular description of the mechanism whereby the osteogenic master gene Osx is controlled post-transcriptionally through a mechanism driven by miR-322/Tob2, strongly suggesting that control of specific mRNA ...
Glioblastoma (GBM) is the most frequent and malignant primary brain tumor. The current standard of care for adult patient with diagnosed GBM is surgery followed by radiotherapy (RT) plus concomitant and adjuvant temozolomide ...
Enzymes are the most proficient catalysts that evolution has developed to assist the chemical reactions that make life possible. By means of molecular simulations the present thesis addresses three aspects of fundamental ...
In marine teleosts that spawn pelagic eggs (pelagophils), the process of oocyte hydration that occurs during meiosis resumption is a key physiological process for the survival of the eggs in the ocean. Previous studies ...
Efficient discovery of bioactive molecules is an essential goal of Computer-Aided Drug Design (CADD). The molecules can be used as chemical probes, to validate novel targets, or as starting points for drug discovery. ...
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream ...
[eng] This thesis addresses molecular segregation in perylene-based systems, including lyotropic chromonic liquid crystals and water-in-water emulsions. These systems offer several advantages compared to conventional ...
In this thesis, the phase behavior in water of a technical grade diglycerol-based surfactant (C41V) and a group of dyes (Quinaldine Red, Pyronin Y, N-Alkylthiacarbocyanines, Oxacarbocyanines, Pinacyanol and Alcian Blue) ...
Los isoprenoides son una de las mayores familias de compuestos descritos en la naturaleza. Estos compuestos están presentes en todos los organismos vivos y se sintetizan a partir de dos moléculas de 5 átomos de carbono: ...
In this doctoral thesis a series of computational and experimental studies of molecular magnetoresistance devices at room temperature is presented. This sort of devices is included in the molecular electronics framework ...
INTRODUCCIÓN: El tratamiento de la enfermedad inflamatoria intestinal se ha basado en el uso de aminosalicilatos corticoides e inmunosupresores, que ayudan a controlar los brotes de la enfermedad, aunque no consiguen su ...
En esta tesis doctoral se han llevado a cabo diferentes estudios dentro del ámbito del magnetismo molecular y la funcionalización de nanotubos de carbono de pared sencilla (SWNT). El magnetismo molecular engloba un amplio ...
[cat] ANTECEDENTS: Els tractaments conservadors utilitzats tradicionalment des del peu —Gait Plate, Torqheel i falca Pronadora—, per les Torsions Tibials Internes —TTI— en nens, basen el seu efecte en la capacitat d'obertura ...
After an intense development of optical tweezers as a biophysical tool during the last decades, quantitative experiments in living cells have not found in this technique its best ally, due, in part, to the lack of a reliable ...
