Mostrando ítems 9628-9647 de 11175
Rodríguez Muñoz, Laura (Fecha de defensa: 2021-05-13)
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, Cic is expressed as ...
Mir Bonnín, Joan Francesc (Fecha de defensa: 2016-07-11)
Previous studies have reported the importance of carnitine palmitoyltransferase (CPT) 1A as an essential part of downstream ghrelin signaling in the central nervous system (CNS) for the control of food intake. Lipid ...
Moreno Càceres, Joaquim (Fecha de defensa: 2016-01-18)
The transforming growth factor-beta (TGF-β) is a cytokine involved in many physiological and pathological processes. Its dual role has been described in the liver, where it can either induce pro- or anti-apoptotic signals. ...
Aparicio García, María (Fecha de defensa: 2020-12-09)
[eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to develop different ...
Jesús Gil, Carmen de (Fecha de defensa: 2021-06-01)
Psoriasis is a common immune-mediated inflammatory skin condition affecting around 2% of the population worldwide. Different disease subtypes have been described regarding their specific clinical phenotype: chronic plaques, ...
Safronova, Elena (Fecha de defensa: 2016-11-04)
Many second language (L2) learners find L2 pronunciation difficult and experience perception and production problems leading to accented speech. There exists a great inter-learner variation in L2 phonological acquisition ...
Hereu Planellas, Mercè (Fecha de defensa: 2019-07-19)
Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...
Martinez Cristobal, Paula (Fecha de defensa: 2016-12-01)
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...
Cuesta Borràs, Estefania (Fecha de defensa: 2019-11-28)
Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. Slow-cycling cancer ...
Ribó Gené, Sílvia (Fecha de defensa: 2017-12-01)
Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...
Pérez Martí, Albert (Fecha de defensa: 2017-03-13)
Obesity and associated metabolic diseases have reached epidemic proportions, affecting not only high-income countries but also low- and middle-income ones. In this context, the search for therapeutic approaches to treat ...
Rosario, Alexandra Carrilho do (Fecha de defensa: 2018-06-12)
This Thesis has been divided into three different chapters, the regulation of Fsp27 during the fasting adaptation, the transcriptional regulation of Fsp27 in liver and finally the role of FSP27 as a lipid-droplet protein ...
López del Hoyo, Natalia (Fecha de defensa: 2014-03-14)
In the last two decades, it has been done a thoroughly research about the role of Guanylate Cyclase Activating Proteins (GCAPs) in photoreceptor cells of the retina as activity regulators of Retinal Guanylate Cyclase ...
Núñez Álvarez, Yaiza (Fecha de defensa: 2017-07-26)
HDAC11 is the newest member of the histone deacetylase (HDAC) family and one of the less studied. Its expression was described to be enriched in skeletal muscle tissues from the first moment of its discovery, yet now after ...
Martínez Garza, Úrsula Montserrat (Fecha de defensa: 2020-11-02)
The excessive consumption of calorie-rich foods, together with a sedentary lifestyle, drive the actual global obesity pandemic. Obesity is the leading cause of several other metabolic disorders, such as diabetes, cardiovascular ...
Román González, Lidia (Fecha de defensa: 2014-01-31)
Within the hematopoietic system, all mature blood cells are generated. Every differentiation step is characterized by the activation of a new, lineage specific, genetic program and the extinction of the previous one. To ...
Arroba Hidalgo, Ester (Fecha de defensa: 2021-02-10)
The human leukocyte antigen-G (HLA-G) is a non-classic MHC class I molecule. It is called “non-classic” because it differs from classic MHC class I molecules due to its very low amount of polymorphism and highly tissue-restricted ...
Petrenko, Aleksei (Fecha de defensa: 2022-09-21)
[spa] INTRODUCCIÓN: El síndrome de hiperestimulación ovárica (SHO) es la complicación yatrogénica más grave y potencialmente mortal asociada con las técnicas de reproducción asistida (TRA). El SHO moderado o grave puede ...
Solé i Codina, Laura (Fecha de defensa: 2013-12-13)
Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin secretion, cell volume ...
Trujillano Fernández, Alejandro (Fecha de defensa: 2024-02-08)
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...