Now showing items 10185-10204 of 11156

    Study of mitochondrial dysfunction mechanisms in Huntington's disease striatal degeneration 

    Cherubini, Marta (Date of defense: 2016-01-15)

    Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder, characterized by progressive behavioral, motor and cognitive deficits (HDCRG, 1993; Ross & Margolis, 2001). The predominant ...

    Study of molecular mechanisms implicated in the TGF-beta oncogenic effect in Glioma 

    Gonzàlez Juncà, Alba (Date of defense: 2013-11-15)

    The TGF-beta oncogenic effect has been widely studied. In glioma, TGF-beta has an oncogenic role increasing cell proliferation and glioma-initiating cell (GIC) self-renewal capacity. During the investigation of this thesis, ...

    Study of natural nanovesicles carrying olfactory receptors for the development of biosensing platforms 

    Sanmartí Espinal, Marta (Date of defense: 2015-01-15)

    Natural vesicles produced from genetically engineered cells with tailored membrane receptor composition are promising building blocks for sensing biodevices. This is particularly true for the case of G-protein coupled ...

    Study of Organic Semiconductors for Device Applications 

    Stella, Marco (Date of defense: 2010-03-12)

    Organic semiconductors are being investigated as an alternative to more traditional materials such as silicon, for the fabrication of different types of electronic devices. The advantages of such materials are flexibility, ...

    Study of pro-apoptotic protein RTP801 homeostasis and its regulation by NEDD4 in Parkinson's disease 

    Canal de la Iglesia, Mercè (Date of defense: 2016-06-01)

    Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons of the Substantia Nigra pars compacta (SNpc) and the presence of cytoplasmic protein inclusions named Lewy Bodies. Current treatments are directed ...

    Study of radiative decays at LHCb and search for the Λb0->pπ-γ decay 

    Alfonso Albero, Alejandro (Date of defense: 2022-02-11)

    The main goal of this thesis is to study the radiative decays produced in one of the four big detectors of LHC, LHCb, which focuses on the study of matter-antimatter asymmetry through b and c quarks. In particular, the ...

    Study of radiotherapy resistance associated to EGFR/MAPK signaling pathway and its application in the rational design of a treatment with simvastatin in combination with cetuximab and radiotherapy (in experimental models of carcinoma) 

    Llobet Cucalón, Lara Isabel de (Date of defense: 2013-11-22)

    1. Generation and characterization of a radioresistant cell line In the first part of this project of Thesis, we subjected culture cells to fractionated radiation and clonal selection, to obtain a modified cohort of ...

    Study of solid particle materials as high temperature Thermal Energy Storage and Heat Transfer Fluid for Concentrating Solar Power 

    Calderón Díaz, Alejandro (Date of defense: 2019-10-24)

    Renewable energies have a major role in today’s energy systems development, energy security and climate change fight. Thermal Concentrating Solar Power (CSP) has the potential to get up to 11.3% of world’s electricity ...

    Study of the aggregation process of the amyloid beta-protein associated to Alzheimer's disease. Examination of pharmaceutically important small molecules. 

    Serra Vidal, Bernat (Date of defense: 2014-05-27)

    Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β (Aβ) protein ...

    Study of the components and adherence to the Mediterranean diet on functional and cognitive ageing: from dietary assessment to a metabolomic approach 

    Tor Roca, Alba (Date of defense: 2023-12-20)

    [eng] Healthy dietary patterns, such as the Mediterranean diet, have been linked to reduced chronic disease risk and mortality. However, the evidence regarding the impact of healthy dietary patterns on physical and cognitive ...

    Study of the components that determine the applicability of pathogenicity predictors in the clinical setting 

    Aguirre Gómez, Josu (Date of defense: 2020-07-14)

    The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from expected. This situation ...

    Study of the conformational dynamics of prolyl oligopeptidase 

    López Asamar, Abraham (Date of defense: 2015-07-17)

    Prolyl oligopeptidase (POP) is an 81-KDa bidomain enzyme which hydrolyses short proline-containing peptides. This enzyme is involved in mnemonic and cognitive processes, and the dysregulation of POP activity is related to ...

    Study of the diffusive properties of extracellular matrix gels used in 3D cultures 

    Galgoczy, Roland (Date of defense: 2013-12-03)

    The extracellular matrix (ECM) hinders diffusion in both tissues and hydrogels used in 3D cultures. However, how geometric and non-geometric ECM properties contribute to diffusion hindrance remains poorly understood. To ...

    Study of the Electron-Transfer properties of phenolics and their relationship with the biological activity on cancer cells 

    Carreras Cardona, Anna (Date of defense: 2012-05-04)

    During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical molecules with high ...

    Study of the expression and regulation of the autocrine loop components of the cyclooxygenase pathway and their implication in aspirin exacerbated respiratory disease 

    Machado de Carvalho, Liliana Sofia (Date of defense: 2015-11-27)

    Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by the combination of nasal polyps (NPs), chronic hypertrophic eosinophilic sinusitis, asthma and severity to any medication that inhibits ...

    Study of the extreme gamma-ray emission from Supernova Remnants and the Crab Pulsar 

    Galindo Fernández, Daniel (Date of defense: 2018-07-27)

    In our Galaxy, supernova remnants and pulsars are the two most numerous populations of non-thermal objects. The goal of this thesis is to study the extreme gamma-ray emission from these two astrophysical objects with Fermi ...

    Study of the Influence of a Combination of Pharmacogenetic Variables on Tacrolimus Exposure: A Population Pharmacokinetic Approach 

    Andreu Solduga, Franc (Date of defense: 2017-09-29)

    The calcineurin inhibitor Tacrolimus (Tac) is used to prevent acute rejection after renal transplant. Unfortunately, the clinical use of Tac is complicated by its considerable toxicity, narrow therapeutic window, and high ...

    Study of the laser forward transfer for the preparation of miniaturized biosensors 

    Duocastella Solà, Martí (Date of defense: 2010-05-17)

    <b>THESIS SUMMARY:</b><br/><br/>The possibility to print tiny amounts of functional materials in a controllable way is of interest in a large number of applications, for instance in the manufacturing of organic electronics, ...

    Study of the metabolic reprogramming associated to metastasis in colon cancer 

    Tarragó Celada, Josep (Date of defense: 2020-09-16)

    Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better comprehension of the process ...

    Study of the molecular mechanisms responsible for E2F1-induced Mtorc1 activation 

    Meo Evoli, Nathalie (Date of defense: 2014-07-07)

    The oncogenic properties of E2F1 have been traditionally associated with the role of the oncogene in proliferation, but during the last few years many other functions associated with this family of transcription factors ...