Universitat de Barcelona
Now showing items 10185-10204 of 11156
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder, characterized by progressive behavioral, motor and cognitive deficits (HDCRG, 1993; Ross & Margolis, 2001). The predominant ...
The TGF-beta oncogenic effect has been widely studied. In glioma, TGF-beta has an oncogenic role increasing cell proliferation and glioma-initiating cell (GIC) self-renewal capacity. During the investigation of this thesis, ...
Natural vesicles produced from genetically engineered cells with tailored membrane receptor composition are promising building blocks for sensing biodevices. This is particularly true for the case of G-protein coupled ...
Organic semiconductors are being investigated as an alternative to more traditional materials such as silicon, for the fabrication of different types of electronic devices. The advantages of such materials are flexibility, ...
Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons of the Substantia Nigra pars compacta (SNpc) and the presence of cytoplasmic protein inclusions named Lewy Bodies. Current treatments are directed ...
The main goal of this thesis is to study the radiative decays produced in one of the four big detectors of LHC, LHCb, which focuses on the study of matter-antimatter asymmetry through b and c quarks. In particular, the ...
1. Generation and characterization of a radioresistant cell line In the first part of this project of Thesis, we subjected culture cells to fractionated radiation and clonal selection, to obtain a modified cohort of ...
Renewable energies have a major role in today’s energy systems development, energy security and climate change fight. Thermal Concentrating Solar Power (CSP) has the potential to get up to 11.3% of world’s electricity ...
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β (Aβ) protein ...
[eng] Healthy dietary patterns, such as the Mediterranean diet, have been linked to reduced chronic disease risk and mortality. However, the evidence regarding the impact of healthy dietary patterns on physical and cognitive ...
The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from expected. This situation ...
Prolyl oligopeptidase (POP) is an 81-KDa bidomain enzyme which hydrolyses short proline-containing peptides. This enzyme is involved in mnemonic and cognitive processes, and the dysregulation of POP activity is related to ...
The extracellular matrix (ECM) hinders diffusion in both tissues and hydrogels used in 3D cultures. However, how geometric and non-geometric ECM properties contribute to diffusion hindrance remains poorly understood. To ...
During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical molecules with high ...
Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by the combination of nasal polyps (NPs), chronic hypertrophic eosinophilic sinusitis, asthma and severity to any medication that inhibits ...
In our Galaxy, supernova remnants and pulsars are the two most numerous populations of non-thermal objects. The goal of this thesis is to study the extreme gamma-ray emission from these two astrophysical objects with Fermi ...
The calcineurin inhibitor Tacrolimus (Tac) is used to prevent acute rejection after renal transplant. Unfortunately, the clinical use of Tac is complicated by its considerable toxicity, narrow therapeutic window, and high ...
<b>THESIS SUMMARY:</b><br/><br/>The possibility to print tiny amounts of functional materials in a controllable way is of interest in a large number of applications, for instance in the manufacturing of organic electronics, ...
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better comprehension of the process ...
The oncogenic properties of E2F1 have been traditionally associated with the role of the oncogene in proliferation, but during the last few years many other functions associated with this family of transcription factors ...
