Now showing items 10797-10816 of 11139

    Uncertainty, interpretability and dataset limitations in Deep Learning 

    Pascual i Guinovart, Guillem (Date of defense: 2023-02-17)

    [eng] Deep Learning (DL) has gained traction in the last years thanks to the exponential increase in compute power. New techniques and methods are published at a daily basis, and records are being set across multiple ...

    Uncivering mechanisms of acquired resistance to trastuzumab-emtansine (T-DM1) in HER2 positive breast cancer 

    Sabbaghi Mehrjardi, Mohammad Ali (Date of defense: 2017-09-19)

    Trastuzumab-emtansine (T-DM1) is an antibody-cytotoxic agent (DM1) conjugated drug. DM1 delivery by trastuzumab inside the HER2 positive cells affects microtubule polymerization, cell cycle arrest and finally cell death. ...

    Uncovering the elements that regulate IKKalpha function in response to DNA damage 

    Alonso Martínez de Marañón, Josune (Date of defense: 2022-12-01)

    [spa] La terapia actual contra la mayoría de los cánceres está basada en el uso de agentes que dañan el ADN, como la quimioterapia o la radioterapia, que erradican las células tumorales proliferantes. Desafortunadamente, ...

    Uncovering the functional organization of molecular interaction networks using network embeddings based on graphlet topology 

    Tello Velasco, Daniel (Date of defense: 2023-09-19)

    [eng] For this purpose, Spatial Analysis of Functional Enrichment (SAFE) framework was proposed to uncover functional regions in a network by embedding it in 2-dimensions (2D) using the Spring embedding algorithm. However, ...

    Uncovering the molecular and cellular mechanisms of metastatic dormancy in luminal breast cancer 

    Cejalvo Andújar, Juan Miguel (Date of defense: 2020-01-22)

    Breast cancer (BC) is the most common cancer in women and it represents the most common cause of cancer-­‐related death in women worldwide1. Advances in early detection, prevention, risk stratification, and therapeutic ...

    Under the Net 

    Gomes Caldeira, Silvia Maria (Date of defense: 2013-01-23)

    Iris Murdoch es una escritora inglesa que tuve el diagnostico de la Enfermedad de Alzheimer (EA) confirmado sea por exámenes clínicos o por el diagnostico histológico post mortem. Por esta razón sus libros se tornaron una ...

    Understanding and predicting magnetic coupling in complex systems: from inorganic complexes to organic polyradicals 

    Reta Mañeru, Daniel (Date of defense: 2016-01-22)

    This thesis presents a theoretical and computational approach to the accurate description of magnetic exchange interactions in a variety of complex systems. These include two main families of compounds. The first family ...

    Understanding chromosomal instability-induced senescence 

    Santos Tapia, Celia (Date of defense: 2019-10-30)

    Aneuploidy, defined as a chromosome number that deviates from a multiple of the haploid set, is a common feature in human cancer, and around 70% of human solid tumours are aneuploid. The resulting metabolic imbalance is ...

    Understanding different opportunities to prevent severe disease and reduce mortality in African infants and children: From vertical transmission prevention to enhanced diagnosis of life-threatening conditions of childhood = Oportunidades para prevenir enfermedades graves y reducir la mortalidad en lactantes y niños africanos. Prevención de la transmisión vertical y mejora del diagnóstico de enfermedades que amenazan la vida de los niños 

    Madrid Castillo, María Dolores (Date of defense: 2018-03-02)

    Infant and child mortality have played a crucial role in health transition patterns and both have been considered as good indicators of development and demographic modernization. The establishment of the Millennium Development ...

    Understanding diversification and dispersion patterns in planarians (Tricladida, Platyhelminthes): form one to hundreds of genes 

    Benítez Álvarez, Lisandra (Date of defense: 2022-06-16)

    Evolutionary Biology offers a set of methods and theories to elucidate the evolutionary processes that lead to the diversification of life. With the development of sequencing technologies, the access to genetic data has ...

    Understanding Entrepreneurial Legitimacy in the digital space: The Where, The Who and The How 

    Arroyo Carrasco, Lizbeth Elaine (Date of defense: 2022-04-25)

    The Industry 4.0 revolution is undergoing a profound transformation due to the unstoppable digitalization of our society. This historic dynamic is characterised by hyperconnectivity, where the Technosphere, the natural ...

    Understanding Innovation within the context of the Integration of Management Systems 

    Hernández Vivanco, Alfonso Antonio (Date of defense: 2018-07-16)

    In an increasingly competitive world driven by fast changes, where resources are limited and where stakeholders are more and more demanding, societies, from individuals to companies and governments, are challenged to pursue ...

    Understanding migration of pelagic seabirds with stable isotopes and geolocation 

    Neto Militao, Teresa Afonso (Date of defense: 2016-10-07)

    Animal migration is an amazing widespread phenomenon that forms an essential component of the animal life history. Animals usually migrate to take advantages of changes in resource availability in space and time or to find ...

    Understanding PI3K signalling in vessel growth and pathophysiology 

    Kobialka, Piotr (Date of defense: 2020-11-13)

    [eng] Our knowledge on the molecular basis behind physiological angiogenesis has significantly expanded in the last two decades. This progress also led to improvement in understanding of many vascular-related diseases in ...

    Understanding Recent Food Price Patterns: A Time-Series Approach 

    Hisham Abdelradi Khalaf, Fadi Mohamed (Date of defense: 2014-10-17)

    The guiding theme of this thesis is the empirical analysis of recent food price behavior. It is composed of three applied studies that address the impacts of energy prices on both food price levels and volatility, as well ...

    Understanding resilience through biodiversity: developing systemic tools for marine conservation in temperate rocky reefs 

    Sanabria Fernández, José Antonio (Date of defense: 2021-01-13)

    The degradation of natural diversity results in the erosion of key systemic properties such as resilience, or the capacity to recover from disturbances. Resilience loss leads to an increase in the fragility and vulnerability ...

    Understanding stochastic and deterministric microbial assembly processes in ephemeral saline lakes 

    Menéndez Serra, Mateu (Date of defense: 2022-06-16)

    Understanding the mechanisms and processes driving biological com- munities assembly, i.e. determining why a specific community is found under certain circumstances, is one of the fundamental questions in ecology. The ...

    Understanding the link between chromatin structure, chromosome conformation and gene regulation 

    Buitrago Ospina, Diana Camila (Date of defense: 2019-12-16)

    Understanding the connection between DNA organization in the nucleus, and cell functioning is one of the most intriguing problems in biology. Although many interdisciplinary efforts have been developed for this aim, the ...

    Understanding the measurements and variability of aerosol optical properties in NE Spain 

    Yus Díez, Jesús (Date of defense: 2022-12-20)

    [eng] Atmospheric aerosol particles are key for regulating Earth’s atmosphere processes, and are estimated to present an overall cooling effect on the Earth’s climate. Given the current climate change crisis, and the need ...

    Understanding the mechanisms of food intake and obesity in Down syndrome is supported by behavioral and neurochemical abnormalities 

    Fructuoso Castellar, Marta (Date of defense: 2017-09-18)

    Obesity prevalence is higher in Down syndrome (DS) than in the general population. Beyond metabolic alterations, individuals with DS present increased impulsivity, a trait observed in obese people and in compulsive eaters ...