Now showing items 5299-5318 of 11175
Llorente Lope, Alicia (Date of defense: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
Amo Maestro, Laura del (Date of defense: 2021-06-11)
The present thesis has established a new and state of the art mammalian protein expression system at the laboratory which has then contributed with high-yield expression for the purification and crystallization of three ...
Ibáñez Sabaté, Maria (Date of defense: 2013-03-05)
The work developed during this PhD has embraced several topics that I divide in three blocks. Each block contains two chapters in this dissertation. Additionally, a general introduction of the different topics is provided ...
Teller Amado, Sara (Date of defense: 2016-02-05)
Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological ...
Sentandreu Benavent, Maria (Date of defense: 2013-01-18)
After germination in darkness, Arabidopsis seedlings follow a dark specific developmental pattern called skotomorphogenesis or etiolation, characterized because the plant develops long hypocotyls together with a closed ...
Benítez i Porras, Francesc (Date of defense: 2016-01-29)
Plasma Polymerization is a novel technique for the preparation of polymer-like thin film coatings at low temperatures onto almost any type of substrates: plastic, metal, semiconductors, wood, textile fibers or membranes, ...
Nikolakopoulou, Myrto-Georgia (Date of defense: 2021-01-29)
Freshwater degradation has been largely attributed to excess nutrient concentrations of anthropogenic origin. Freshwater degradation in combination with water scarcity are the reason of severe stress on water resources ...
Cardó i Vila, Marina (Date of defense: 2003-07-25)
Macrophages require presence of M-CSF to survive and proliferate. Incubation of bone marrow macrophages with soluble factors (LPS or IFN-gamma) or insoluble factors such as extracellular matrix proteins (Decorin, FN) ...
Rubio Patiño, Camila (Date of defense: 2012-10-31)
Glucocorticoids (GC) induce cell cycle arrest and apoptosis in different cell types and therefore are widely used to treat a variety of diseases including autoimmune disorders and cancer. This effect is mediated by the GC ...
Polat, Ibrahim H. (Date of defense: 2016-11-04)
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...
Delgado Martin, Gonzalo (Date of defense: 2014-07-14)
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...
Eibes González, Susana (Date of defense: 2016-09-13)
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this process: cyclin- ...
Robotti, Marco (Date of defense: 2016-09-29)
The main subject of this PhD Thesis is the manufacturing of titanium dioxide multifunctional coatings by means of two spraying technologies: Cold Gas Spray (CGS) and Atmospheric Plasma Spray (APS). The characteristics of ...
Martín Vilardell, Anna (Date of defense: 2017-01-25)
The Cold Spray (CS) is a novelty technique for the production of coatings within the field of Thermal Spray. The use of low work temperatures (under the melting point of the material) is what makes it different from the ...
Sirczuk, Matías (Date of defense: 2013-10-09)
¿Cómo fundar regímenes políticos duraderos cuando resulta imposible encontrar un polo incondicionado desde el cual derivar la legitimidad de la ley? ¿Cómo establecerlos en las condiciones políticas de la modernidad, en una ...
Planas Corbella, José María, 1910-1936 (Date of defense: 1934-06-16)
En una serie de recientes trabajos, donde se estudian a fondo muchos problemas esenciales de la moderna teoría de las funciones de dos variables complejas, F. SEVERI ha establecido las bases de una fundamentación geométrica ...
Muñoz Del Valle, Santiago (Date of defense: 2023-02-02)
[spa] La presente investigación pretende ocuparse de los fundamentos de la filosofía de la historia de Walter Benjamin a partir de una lectura pormenorizada de ciertos textos que consideramos esenciales. Estos fundamentos ...
Meseguer Penalva, María José (Date of defense: 2002-12-13)
El desarrollo sostenible (art. 2 Tratado de Ámsterdam de 1997) persigue la finalidad de la calidad de vida del ser humano (Preámbulo y art. 45.2 Constitución Española) en su dimensión intra e inter generacional. La ...
Ramírez Sarrió, Dídac, 1946- (Date of defense: 1988-01-01)
La importancia creciente que la incertidumbre tiene en economía no se ha visto correspondida por una atención suficiente a las cuestiones de fundamentación, desde el punto de vista conceptual, lógico y eidométrico. La tesis ...
Zapata García, Pedro A. (Date of defense: 2018-03-16)
Este trabajo desarrolla una lectura unificada de la responsabilidad patrimonial de la Administración Pública. De esta manera, al tiempo que se aparta de la clásica distinción de la responsabilidad contractual y extracontractual, ...