Ara mostrant els elements 11-20 de 353
Glaría Percaz, Estibaliz (Data de defensa: 2021-06-16)
Macrophages exert potent microbicidal functions against pathogens; however, some intracellular bacteria have developed strategies to survive within intracellular phagolysosomes and use macrophages as a ...
Brenchat Barberà, Àlex (Data de defensa: 2012-03-26)
The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project ...
Torrealba Sandoval, Débora Alejandra (Data de defensa: 2016-06-03)
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual ...
Angulo Urarte, Ana (Data de defensa: 2017-02-24)
Class IA PI3K (PI3K) functions have been widely investigated over the last two decades. PI3K signalling is located at the crossroads of many cell surface receptors sending signals to coordinate multiple ...
Eibes González, Susana (Data de defensa: 2016-09-13)
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this ...
Canals Buj, Meritxell (Data de defensa: 2004-04-16)
Adenosine and dopamine receptors are members of the GPCRs family for which a significant segregation between their A2A and D2 subtypes has been demonstrated in the GABAergic striopallidal neurons of the ...
Escobedo Pascual, Albert (Data de defensa: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Villamor Payà, Marina (Data de defensa: 2021-07-08)
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute ...
Ramírez Cota, Rosa María (Data de defensa: 2016-07-05)
The depletion of MZT1 in human cells causes severe mitotic spindle defects. Depleted cells lack centrosomal γ-tubulin and arrest in mitosis with a monopolar spindle configuration. Similarly, double ...
Chivite Araiz, Íñigo (Data de defensa: 2020-01-24)
Blood vessels distribute nutrients and oxygen to every single cell in the body. Endothelial cells define the vessel wall, and thus they are ideally located to crucially modulate nutrient availability ...