Fernández Plana, Julen (Date of defense: 2019-01-09)
El tractament de quimioteràpia associada a fàrmacs anti-EGFR representa un estàndard de tractament oncològic per a un subgrup de pacients amb Càncer colorectal metastàtic (CCRm). Malgrat això, no tots ...
Bazzocco, Sarah (Date of defense: 2016-01-27)
Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of ...
Moreta Moraleda, Cristina (Date of defense: 2022-01-25)
The hypothesis of the present thesis is that the presence or absence of some chromatin factors may facilitate or impair the action of chemotherapeutic drugs in colorectal cancer (CRC). Chromatin factors ...
Badia Ramentol, Jordi (Date of defense: 2020-01-14)
Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which ...
Riaño Canalias, Ferran (Date of defense: 2017-09-29)
Ribosome biogenesis is one of the most energy consuming anabolic processes in a cell, required for the generation of the translational machinery to grow and proliferate. Moreover, this process necessitates ...
Ramírez Corpas, Lorena (Date of defense: 2023-01-20)
[spa] Alrededor del 10% de los pacientes con cáncer colorrectal metastático (mCRC) presentan la mutación BRAF(V600E), mutación que está asociada a una peor respuesta al tratamiento estándar con agentes ...
Tasende Presedo, Marta María (Date of defense: 2018-01-11)
ANTECEDENTES: El abordaje quirúrgico de la patología rectal ha sido desde siempre un reto para el cirujano, debido a que su localización anatómica en la pelvis dificulta el acceso al mismo, disección ...
García de Albéniz, Xabier (Date of defense: 2015-04-15)
We studied the mechanisms driving the metastatic spread in colorectal cancer (CRC), focusing in the MAPK pathway. We developed in vivo a highly metastatic cell line using a KRAS-mutated cell line (SW620) ...
Díaz Gay, Marcos (Date of defense: 2019-11-25)
Colorectal cancer (CRC) is one of the malignant neoplasms with higher incidence and mortality in Spain, Europe and worldwide. As a complex disease, both environmental and genetic factors influence CRC ...
Jung, Gerhard (Date of defense: 2023-09-22)
[spa] El Cáncer Colorrectal (CCR) representa un importante problema de salud pública, situándose como el tercer cáncer más frecuente tanto en España como en la Unión Europea, y siendo una de las principales ...