Mostrando ítems 31-40 de 56
Súarez López, Lucía (Fecha de defensa: 2013-07-05)
Durante la división celular, el ADN debe estructurarse en cromosomas para asegurar un correcto reparto de la información genética a las dos células hijas. El complejo condensina, junto con el motor ...
Martínez Redondo, Paloma (Fecha de defensa: 2014-06-25)
The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded ...
Terribas Pérez, Ernest (Fecha de defensa: 2016-01-20)
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 ...
Rodilla Martín, Ananda Marina (Fecha de defensa: 2018-04-10)
Oral and lung cancer are included in the most prevalent respiratory diseases, being the latter one of the main causes of mortality worldwide. Despite new advances in diagnosis and clinical care, success ...
Fernández Alfara, Marcos (Fecha de defensa: 2022-04-07)
Translation of mRNAs into proteins is a highly regulated step of gene expression. In cancer, post-transcriptional and translational control have a critical effect on transformation, controlling ...
Franco Valls, Héctor (Fecha de defensa: 2022-05-26)
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast ...
Cortés Hinojosa, Marlies (Fecha de defensa: 2017-05-26)
ZEB1 is a transcription factor whose expression in cancer cells promotes tumor initiation and progression. In this study, we for the first time characterized Zeb1 and study its function in macrophages ...
Moreno Cabrera, José Marcos (Fecha de defensa: 2021-06-17)
This PhD thesis has been carried out with the aim of improving, from a bioinformatic-based approach, the genetic diagnostics of hereditary cancer. More specifically, the aims were: 1. To perform a ...
Esteve Arenys, Anna (Fecha de defensa: 2017-12-22)
Lymphomas are a heterogeneous group of tumors characterized by the proliferation of lymphocytes predominantly in lymphoid structures but also in extranodal tissues. More than 90% of patients are ...
Recasens Zorzo, Clara (Fecha de defensa: 2018-06-19)
Constitutive activation of the chemokine receptor CXCR4 is associated with tumor progression, invasion and resistance to treatment. Overexpression of CXCR4 in diffuse large B-cell lymphoma (DLBCL) confers ...