Coronas Serna, Luis Enrique (Date of defense: 2023-03-28)
[eng] This thesis develops, validates, and explores applications of the Franzese-Stanley (FS) coarse-grained model for bulk water, ultimately intended to represent the solvent in large-scale simulations ...
Arroyo Sánchez, Rodrigo (Date of defense: 2014-06-20)
Network and systems biology disciplines could revolutionize the study of complex diseases by taking proteins back to their context, considering a much broader perspective of their environment without ...
Viel Oliva, Albert (Date of defense: 2017-06-16)
Els nucleòsids són metabòlits imprescindibles per a la cèl·lula ja que són els precursors d’un gran nombre de biomolècules. Aquests nucleòsids poden ser sintetitzats per la cèl·lula o es poden recuperar ...
Martinez Cristobal, Paula (Date of defense: 2016-12-01)
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear ...
Fuster Juncà, Cristina (Date of defense: 2019-06-14)
The research work presented in this thesis aims to understand the transport mechanism of two described BBB-shuttles, THRre and MiniAp-4. To achieve these objectives, different techniques have been used ...
Frigolé Vivas, Marta (Date of defense: 2020-09-23)
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to ...
Pons Pons, Alba (Date of defense: 2021-12-16)
SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog ...
Peró Gascón, Roger (Date of defense: 2020-11-03)
En las últimas décadas, el análisis de compuestos biomarcadores en muestras biológicas se ha convertido en una herramienta esencial para el diagnóstico, seguimiento y pronóstico de diversas enfermedades. ...
Tur Torres, Juan (Date of defense: 2017-03-22)
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability ...
López Martínez, Montserrat (Date of defense: 2017-09-26)
Electron Transfer (ET) plays essential roles in crucial biological processes such as cell respiration and photosynthesis. It takes place between redox proteins and in protein complexes that display an ...