Garcia Cabau, Carla (Date of defense: 2022-05-31)
Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation ...
Coronas Serna, Luis Enrique (Date of defense: 2023-03-28)
[eng] This thesis develops, validates, and explores applications of the Franzese-Stanley (FS) coarse-grained model for bulk water, ultimately intended to represent the solvent in large-scale simulations ...
Frigolé Vivas, Marta (Date of defense: 2020-09-23)
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to ...
Pons Pons, Alba (Date of defense: 2021-12-16)
SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog ...
Peró Gascón, Roger (Date of defense: 2020-11-03)
En las últimas décadas, el análisis de compuestos biomarcadores en muestras biológicas se ha convertido en una herramienta esencial para el diagnóstico, seguimiento y pronóstico de diversas enfermedades. ...
Rupérez Gonzalo, Celia (Date of defense: 2020-09-10)
El objetivo principal de esta tesis fue el estudio de la función de dos nuevas cardiocinas, FGF21 y Metrnl, durante el desarrollo de la patología cardíaca. Se dividió en los siguientes apartados: PARTE ...
Barrera Vilarmau, Susana (Date of defense: 2022-03-15)
La abrazadera deslizante eucariota (PCNA), juega un papel esencial como componente del replisoma. PCNA, de forma toroidal, rodea el DNA y ata las polimerasas y otros factores a la plantilla genómica ...
Iruela Martin, Guillermo (Date of defense: 2021-09-16)
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack ...
Martín Romero, Jesús (Date of defense: 2022-09-16)
[spa] Mycoplasma pneumoniaees una bacteria patógena humana sin pared celular que causa neumonías atípicas y otras infecciones respiratorias. Es una de las pocas especies de procariotas que necesitan ...
Ortega Gascó, Alba (Date of defense: 2023-07-07)
[eng] The Central Nervous System (NS) is a fascinating and complex structure formed by millions of interconnected neurons that facilitate cognitive tasks such as memory and learning. The development and ...