Díaz Perlas, Cristina (Date of defense: 2018-03-07)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) ...
Fransen, Peter (Date of defense: 2013-12-05)
Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the ...
Adrián Izquierdo, Javier (Date of defense: 2012-09-28)
The indiscriminate and/or improper use of veterinary drugs is the cause of potential adverse health effects due to the risk of entering into the food chain and the appearance of residues in food products ...
Defaus Fornaguera, Sira (Date of defense: 2014-06-20)
Glycosylation is a posttranslational modification affecting the fast majority of cellular surfaces through glycolipids and glycoproteins. It has been estimated that over 80% of all proteins are glycosylated ...
Fernández-Llamazares Onrubia, Ana Iris (Date of defense: 2013-12-09)
Backbone N-methylation is becoming an increasingly important tool in peptide drug design, and has been widely used to optimize the activity and selectivity of peptide ligands as a result of conformational ...
Vázquez Jiménez, Laura (Date of defense: 2014-11-25)
Oxidative stress is one of the most important factors in degenerative diseases like cancer, Alzheimer or in episodes like ischemia. During these processes, reactive species of oxygen (ROS) and nitrogen ...
Lafuente Fabra, Maria (Date of defense: 2018-07-18)
The present research project can be included in the broad supramolecular chemistry field that was defined by Nobel laureate Jean Marie Lehn as the "chemistry beyond the molecule".1 It is based on processes ...
Vilaprinyó Pascual, Sílvia (Date of defense: 2015-07-27)
Amyloid-beta protein (Aß) is strongly linked to the aetiology of Alzheimer’s disease (AD). Even though Aß has a central role in AD, this protein is normally produced in healthy humans. It is the aberrant ...
Romo Fernández, Juan Manuel (Date of defense: 2015-06-22)
In this Doctoral Thesis a new stereoselective Ni(II)–mediated catalytic system for the SN1–like addition of chiral Nacyl thiazolidinethiones to electrophiles able to deliver cationic species under ...
Pelay Gimeno, Marta (Date of defense: 2013-02-15)
Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, ...