Nicolini, Federica (Date of defense: 2022-12-02)
[eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. ...
Hervés Carrete, Carmen (Date of defense: 2023-05-24)
[eng] The main objective of this dissertation has been to stablish a bridge between materials science and its fields of application. The scope of this thesis work, under this premise, is aimed towards ...
Atcher Ubiergo, Joan (Date of defense: 2015-07-28)
Dynamic combinatorial chemistry proposes the creation of a library of compounds (dynamic combinatorial library, DCL) inter-connected through reversible chemical processes. The concentrations in a DCL ...
Balaceanu, Alexandra (Date of defense: 2018-12-12)
1. The Force Field Accuracy Problem. The utility and applicability of MD simulations to model biomolecular systems goes only as far as its ability to sufficiently sample the conformational space and ...
Schirinzi, Gabriella Francesca (Date of defense: 2020-06-10)
In recent decades, global plastics production and consumption have continued to increase. Although many policy strategies on waste prevention and recycling have been implemented, much of the plastic ...
Salmatonidis, Apostolos (Date of defense: 2019-09-30)
Exposure to nanoparticles has been associated with adverse effects on human health. When the exposure route is inhalation, nanoparticles can cause pulmonary inflammation which may be more severe than ...
Alagia, Adele (Date of defense: 2015-12-11)
To direct post-transcriptionally gene silencing, RNAi machinery exploits the formation of base pairs between the loaded guide strand and the complementary mRNA. The Ago2 protein is the “slicer” effector ...
Panarello, Silvia (Date of defense: 2021-12-15)
Photopharmacology has the main purpose to allow the control of protein activity with light. The most exploited strategy used to achieve this objective is the freely diffusible photopharmacology and it ...
Mendive Tapia, Lorena (Date of defense: 2017-02-17)
In the present thesis we have investigated the development of new methodologies for the selective and straightforward chemical modification of Trp amino acid either alone or in peptides. In the first ...
Barbieri, Maria Vittoria (Date of defense: 2021-01-28)
The assessment of pesticide occurrence in different environmental compartments has become a matter of outstanding importance since its effects on exposed organisms may be considered a warning on the ...