Gil Escolano, Alejandro (Date of defense: 2018-02-16)
Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands ...
Puig Castellví, Francesc (Date of defense: 2018-07-10)
Nuclear Magnetic Resonance (NMR) spectroscopy is able to produce by a single direct measurement a very high amount of chemical information. However, this information is not always easy to interpret. In ...
Ninot Pedrosa, Martí (Date of defense: 2018-03-02)
Amyloid-beta peptide (Aβ) is strongly linked to the aetiology of Alzheimer’s disease (AD). Aβ is the main component of the amyloid plaques found in the brain of AD patients, however, Aβ is also present ...
Serra Vidal, Bernat (Date of defense: 2014-05-27)
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β ...
Guixer, Bernat (Date of defense: 2014-03-31)
The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct ...
Gorrochategui Matas, Eva (Date of defense: 2018-04-20)
Lipidomics is a subset of metabolomics, which in turn, is one of the categorical platforms that constitute omics. Omic sciences aim at the study of the abundance and (or) structural characterization of ...
Sánchez Martínez, Melchor (Date of defense: 2014-12-09)
Proteins are flexible entities, and thus move. Its function is closely related to the flexibility. To carry out any function is necessary a conformational change. As protein motions imply an exchange ...
Portell Bueso, Anna (Date of defense: 2014-11-17)
This thesis is a multidisciplinary study of the solid state of squaric acid derivatives which combines approaches from areas such as crystal engineering, supramolecular chemistry and crystallography. ...