Mostrando ítems 21-30 de 34
Pérez Cano, Laura (Fecha de defensa: 2013-06-28)
Computational methods are increasingly important to help to predict and characterize protein interactions. However, most of the efforts so far have focused on protein-protein and protein-ligand interactions, ...
Isasa Catalán, Marta (Fecha de defensa: 2012-07-19)
Targeted protein degradation plays a central role in eukaryotic cell regulation and homeostasis. The ubiquitin proteasome system (UPS) is involved in a large number of cellular events, being, day by ...
Roig Merino, Sara Raquel (Fecha de defensa: 2017-05-05)
Voltage-gated potassium channels are proteins that allow the flux of potassium ions across the plasma membrane in response to a voltage stimulus. Those proteins were initially described in nervous system ...
Rodríguez Lumbreras, Luis Ángel (Fecha de defensa: 2023-04-18)
[eng] The study of the 3D structural details of protein-protein and protein-DNA interactions is essential to understand biomolecular functions at the molecular level. Given the difficulty of the structural ...
Marín de Mas, Igor Bartolomé (Fecha de defensa: 2015-03-20)
The general aim of this thesis is to develop and apply new computational tools to overcome existing limitations in the analysis of metabolism. This thesis is focused on developing new computational ...
Álvarez Marimón, Mª Elena (Fecha de defensa: 2014-10-27)
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide ...
Arimany Nardi, Cristina (Fecha de defensa: 2013-12-03)
Nucleoside-derived drugs are used for the treatment of haematological malignancies, viral infections and autoimmune or inflammatory diseases. These drugs require membrane transporters to be internalised ...
Benito Mauricio, Adrián (Fecha de defensa: 2014-02-21)
The present doctoral thesis is focused on the metabolic adaptations induced by oncogene activation as well as the potential role of the metabolic network as antitumor therapy. Over the last years, it ...
Codó Tarraubella, Laia (Fecha de defensa: 2019-12-03)
Recently, research processes in Life sciences have evolved at a rapid pace. This evolution, mainly due to technological advances, offers more powerful equipment and generalizes the digital format of ...
Rotondo, Floriana (Fecha de defensa: 2018-02-19)
The current theories about endothelial inflammation in the adipose tissue in metabolic syndrome point to hypoxia as one of its main causes. Nevertheless, our group has found that both 3T3L1 adipocytes, ...