Mugianesi, Francesca (Date of defense: 2022-06-02)
Gene expression, epigenetic states and topological conformation are three fundamental aspects of genome organization that are tightly regulated in space and time. Epigenetic states, protein occupancy ...
Pascual-Reguant, Laura (Date of defense: 2018-11-23)
Les làmines nuclears (A/C i B) són els majors constituents de la làmina nuclear (NL). Els estructuralment conservats dominis associats a les làmines (LADs) estan formats per regions genòmiques que ...
Posavec, Melanija (Date of defense: 2014-06-17)
MacroH2A1.1 is one of the least understood histone variants and structural components of chromatin. Generated by alternative splicing, macroH2A1.1 differs from the other macroH2A1 isoform in its ...
Sancho Medina, Mònica (Date of defense: 2008-05-30)
At least eleven histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition of ...
Corrales Berjano, Marc (Date of defense: 2018-01-19)
This thesis reports the study of chromatin composition and conformation on the expression of integrated reporters at thousands of genomic locations in the Drosophila genome. We have adapted and improved ...
Mocavini, Ivano (Date of defense: 2022-03-31)
Polycomb repressive complex (PRC)1 and 2 are major players in gene regulation, devoted to maintenance of the epigenetic memory of gene silencing. Mouse embryonic stem cells (mESCs) have been extensively ...
Teichmann, Sophie (Date of defense: 2013-02-04)
La monoubiquitinación de la histona H2A cumple un rol esencial en la represión génica. Diversas enzimas desubiquitinantes (DUBs) han sido identificadas, que remueven específicamente la ubiquitina de ...
Ortells Campos, Mª Carmen (Date of defense: 2012-07-26)
Adaptive responses allow cells to maintain their growth as well as their proliferative potential under diverse stress conditions. It is known that, growth and proliferation can be suppressed by intense ...
Bauer, Moritz (Date of defense: 2020-02-14)
The reactivation of the inactive X chromosome has the potential to provide a unique system to study the developmentally induced formation of euchromatin. However, insights into this process were hampered ...
Agirre Ortiz de Guzmán, Eneritz (Date of defense: 2013-06-21)
Generalment s'ha pensat que la regulació de l'splicing alternatiu està controlada principalment per la interacció entre els factors reguladors de l'splicing i la taxa d'elongació de la ARN polimerasa ...
575 - General genetics. General cytogenetics (10)
576 - Cellular and subcellular biology. Cytology (8)
577 - Material bases of life. Biochemistry. Molecular biology. Biophysics (7)
616 - Pathology. Clinical medicine (2)
616.7 - Pathology of the organs of locomotion. Skeletal and locomotor systems (1)