Mostrando ítems 21-40 de 42
Serra i Figueras, Olga (Fecha de defensa: 2008-12-12)
La caracterització funcional de dos gens en la peridermis, la ω hidroxilasa d'àcids grassos CYP86A33 -candidata per la funcionalització del carboni ω-terminal dels monòmers alifàtics de la suberina- i la ...
Camprubí Font, Carla (Fecha de defensa: 2019-07-26)
The adherent-invasive Escherichia coli (AIEC) pathotype could play a role in the course of Crohn’s disease. This is characterized by its capacity to adhere to and to invade intestinal epithelial cells as well as to replicate ...
Tabarés Carreras, Glòria (Fecha de defensa: 2004-03-19)
Als països desenvolupats, una de cada cinc persones morirà a causa del càncer. S'ha descrit que les cèl·lules canceroses presenten modificacions en els glicans presents a la superfície cel·lular i aquesta glicosilació ...
Blanco Aparicio, Carmen (Fecha de defensa: 1998-07-17)
In this work we report that potato carboxypeptidase inhibitor suppresses the growth of several human and mouse pancreatic adenocarcinoma cell lines. The inhibitor also reduces the growth of solid tumors obtained by ...
Torrent Albertí, Gerard (Fecha de defensa: 2009-03-27)
La primera part d'aquest treball s´ha centrat en la caracterització i optimització del procés d'activació de l´onconasa recombinant per tal d'obtenir l´enzim igual a la forma nativa. Per això, les reaccions d'eliminació ...
Llavanera Bruguera, Marc (Fecha de defensa: 2023-05-12)
Male infertility is a global health problem affecting one in four infertile couples. This also has a negative repercussion on the animal breeding industry, where infertility has a detrimental impact on their balance sheets. ...
Vert Company, Anna (Fecha de defensa: 2014-07-30)
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
Ferri Iglesias, María José (Fecha de defensa: 2012-09-27)
Serum levels of several molecules associated to pancreatic adenocarcinoma (PDAC) pathophysiology are evaluated in this work, in order to determine their diagnostic value, distinguishing between PDAC patients and healthy ...
Duran Sidera, Adrià (Fecha de defensa: 2023-11-14)
Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis of the disease at ...
Oliveras Ferrarós, Cristina (Fecha de defensa: 2013-06-21)
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
Balmaña Esteban, Meritxell (Fecha de defensa: 2016-07-07)
Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest ...
Font i Sadurní, Josep (Fecha de defensa: 2006-06-02)
Utilitzant temperatura i pressió com a agents desnaturalitzants s'ha explorat la contribució a l'estabilitat de diferents residus del principal nucli hidrofòbic de la RNasa A. Aquests resutats suggereixen que el principal ...
Coll Constans, M. Gràcia (Fecha de defensa: 2000-03-31)
Bovine pancreatic ribonuclease A (RNase A, EC 3.1.27.5) has been extensively studied from the structural, mechanistic and functional points of view. Within the protein folding context, it constitutes a good ...
Ribó i Panosa, Marc (Fecha de defensa: 1994-12-16)
The answer to whether or not, human pancreatic ribonuclease may have a diagnostic value as a serum marker of pancreatic disease, depend upon the specific detection of ribonucleases originated in pancreas amogn those ...
Bassagañas i Puigdemont, Sònia (Fecha de defensa: 2014-12-03)
Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and ...
Díaz Roldán, Ferran (Fecha de defensa: 2023-07-03)
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...
Viñolas Vergés, Estel (Fecha de defensa: 2023-07-27)
Male fertilising capacity has traditionally been predicted by the assessment of sperm concentration, motility and morphology. During the last few decades, however, research has been particularly focused on the analysis of ...
Arribas Bosacoma, Raquel (Fecha de defensa: 2009-07-22)
Es presenta el model atòmic a 4.5 Å de DnaB, la principal helicasa replicativa bacteriana, d'Aquifex aeolicus. És un anell hexamèric de 100 Å d'amplada i 80 Å d'alçada amb dues capes de simetria diferenciada, la dels dominis ...
Pérez Garay, Marta (Fecha de defensa: 2011-02-07)
Este trabajo demuestra que los genes que codifican para los enzimas beta-galactosido alfa-2,3-sialiltransferasa 3 (ST3Gal III), y en menor medida beta-galactosido alfa-2,3-sialiltransferasa 4 (ST3Gal IV), están directamente ...
Ruiz Martínez, Santiago (Fecha de defensa: 2016-07-08)
The main aim of the present study is to characterize the biological and biophysical properties of Apoptin, a viral protein that selectively induces apoptosis of a wide range of tumor cells. Apoptin has been produced and ...