Departament de Ciències Mèdiques: Recent submissions
Now showing items 21-40 of 114
Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...
Posible rol de las neuregulinas en la fisiología del tejido adiposo en asociación con obesidad y diabetes mellitus tipo 2
Different studies link the metabolic alterations of obesity with imbalances in neuregulin 4 levels. In this study we hypothesize that signaling of neuregulin isoforms (NRG) produced through ERBB receptors in human adipose ...
Methylome profiling of B and T cells along multiple sclerosis disease progression: a pilot study
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune and neurodegenerative disease characterized by the infiltration of autoreactive immune cells into the central nervous system that leads to axonal damage, ...
L’extracte de fulla d’olivera redueix la pressió arterial de pacients amb hipertensió arterial lleugera sense malaltia vascular subclínica
Introduction: Hypertension is the common cardiovascular risk factor and affects 20 to 50% of the population. Treatment, with drugs or not, involves improving lifestyle. Olive leaf extract has traditionally been taken to ...
Study of two analogues of pituitary adenylate cyclase-activating polypeptide as novel therapeutic compounds for Huntington’s disease
Huntington’s disease (HD) is a neurodegenerative genetic disorder with no effective treatment characterized by motor discoordination, deficits in cognitive function (acquiring new knowledges, memory, understanding…), and ...
Estudi de l’alliberació del calci intracel·lular en cardiomiòcits derivats de iPSC de pacients amb taquicàrdia ventricular polimòrfica catecolaminèrgica (CPVT)
In a small region of the island of Gran Canaria, 11 cases of sudden cardiac death (SCD) were registered in emotional or physical stress situations in young individuals between 1994 and 2007 in four seemingly unrelated ...
New approaches for the study and treatment of aggressive cancers
Although there are therapies for triple negative breast cancer (TNBC) and epidermal growth factor-mutated non-small cell lung cancer (EGFRm NSCLC), these two subtypes of cancer are very aggressive, and most patients develop ...
Estudio de la regulación génica en el locus SCN5A-SCN10A y su implicación en la etiología del Síndrome de Brugada
Brugada syndrome (SBr) is a cardiac electrical disease associated with a high susceptibility to ventricular arrhythmias and sudden cardiac death. Genetic variants in the coding regions of the SCN5A gene, which encodes for ...
Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of ...
Nova metodologia d’anàlisi de distribucions de dosi per algorismes de càlcul de dosi absorbida en radioteràpia externa que simulen el transport de radiació en medi
Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...
Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada
Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...
Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent
INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...
Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification
Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...
Caracterización de polimorfismos genéticos implicados con el metabolismo de la citarabina y asociación con la respuesta y toxicidad a la quimioterapia en pacientes con leucemia mieloide aguda de riesgo intermedio
Acute myeloid leukemia (AML) is adults' most common acute leukemia. Prognostic factors influencing treatment response and patient survival are diverse, the most relevant being those associated with specific cytogenetic and ...
Estudio del impacto de UGT2B17 y PD-1 en el trasplante alogénico de progenitores hematopoyéticos a partir de donante emparentado HLA idéntico
Study of the impact of UGT2B17 and PD-1 on allogeneic transplantation of hematopoietic progenitors (allo-TPH) from HLA-identical related donor. everal genetic factors can favor the development of graft-versus-host disease ...
Identificación y caracterización de factores de transcripción implicados en la regulación de procesos moleculares y cerebroreparadores en el ictus
The aim of this thesis was to identify transcriptional regulators involved in the modulation of ischaemia, as well as brain plasticity processes responsible for compensating the ischaemic lesions, in order to establish the ...
Reinterpretació de les variants genètiques identificades en una unitat especialitzada en cardiopaties familiars
Sudden cardiac death (SCD) is defined as a natural and unexpected death due to cardiac etiology. In addition, when the cause of death remains unexplained after a complete autopsy, a cardiac arrhythmia is suspected as a ...
Valoració dels canvis que pateix la uretra durant l’embaràs objectivats per ecografia 2D i la relació d’aquests amb l’aparició d’incontinència d’orina en la gestació
Urinary incontinence (UI) is a dysfunction that has a very negative impact on the quality of life of women who suffer from it (low self-esteem, shame, restriction of social contacts, etc.). Different factors involved in ...
L’àcid úric, el greix perirenal i la mida renal com a nous marcadors de risc cardiovascular en població pediàtrica sana
Despite notable advances in health promotion over the past decades, cardiovascular disease remains the leading cause of death worldwide, with obesity being a rising contributor of it. Cardiovascular risk factors appear in ...
Estudio anatómico y funcional del ligamento colateral ulnar lateral. Análisis de su papel en la inestabilidad postero-lateral
We performed a descriptive and functional experimental study in various phases of the lateral elbow liamentous complex (LCL), with special relevance to the function of the lateral ulnar collateral ligament (LCUL). Initially,we ...
