Àrea de contingut
Universitat de Barcelona
Listando Departament de Farmacologia, Toxicologia i Química Terapèutica por título
Mostrando ítems 1-20 de 58
Addressing Alzheimer's disease through innovative mechanisms
[eng] Alzheimer’s disease (AD) remains a major unmet medical need, with no effective disease- modifying treatments available despite decades of research and a growing socioeconomic burden associated with its increasing ...
Characterization of epigenetic and transcriptional changes in aging and Alzheimer’s disease
Epigenetic changes are currently recognized as part of the aging process and have been implicated in many age-related chronic diseases such as Alzheimer’s disease (AD). The term epigenetics includes a variety of processes ...
Chiral tricyclic lactams as efficient enantiomeric scaffolds for the synthesis of cis-decahydroquinolines substituted on the carbocyclic ring. Total synthesis of Myrioneuron alkaloids
[eng] The Myrioneuron alkaloids constitute a family of natural products found in East and South-East Asia. They feature a cis- or trans-decahydroquinoline (DHQ) as a common unit, attached to an oxazine, a diazine, or a ...
Chloroacetamides as Valuable Synthetic Tools to Access Nitrogen-Containing Heterocycles Using Both Radical and Non-Radical Processes
Durante este trabajo de tesis doctoral se ha demostrado que las cloroacetamidas son intermedios de gran utilidad para la síntesis de heterociclos nitrogenados a través de procesos radicalarios o no radicalarios. En este ...
Common scaffolds for the enantioselective synthesis of marine, plant, and amphibian cis-decahydroquinoline alkaloids
Chiral amino alcohol derived lactams are a valuable scaffold for the enantioselective synthesis of alkaloids. In the present thesis the potential of this methodology was expanded and to demonstrate the synthetic utility ...
Design and synthesis of heterocyclic compounds potentially antitumor by enzymatic inhibition
This doctoral thesis is focused on the investigation and development of new compounds directed to different cancer and tropical diseases targets. Drug resistance, as well in cancer as in tropical diseases, is a hurdle which ...
Design and synthesis of sphingosine-1-phosphate lyase inhibitors and fluorogenic probes for the development of HTS assays
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. An important group of SLs metabolites are those showing a phosphate group at the C1‒ OH. Among them, sphingosine‒1‒phosphate (S1P) ...
Development of a divergent strategy towards the synthesis of lycopodium alkaloids
En la present tesi doctoral s’ha desenvolupat una estratègia per obtenir els esquelets dels quatre alcaloides licopodi representatius a partir d’un mateix intermedi sintètic comú 1, de manera semblant al procés que té lloc ...
Development of Iron-Catalyzed Hydrogen Atom Transfer Driven Cross-Coupling and Cyclization Reactions: Use of Isocyanides, Heterocycles and Tosylhydrazones as Radical Acceptors
[eng] Radical reactions have been proven valuable tools in C-C bond generation because the initial radical can evolve to form additional C-C bonds until the new radical species is trapped. With the careful design of the ...
Development of New Multicomponent Processes based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications
1. It was observed that the interaction of imines and isocyanides in the presence of a Lewis acid can lead to a variety of scaffolds including α-aminoamides, α-aminoamidines, indoles and diiminoazetidines. The reaction ...
Developmental toxicity screening in the zebrafish embryo – a metabolomics approach
[eng] Birth defects occur in about 3-6% of human births worldwide (CDC, 2023). To mitigate the risk to the unborn child, the assessment of embryo-fetal developmental toxicity is an integral part of chemical registration ...
El déficit cognitivo y la enfermedad de Alzheimer en presencia de alteraciones metabólicas: Estudio in vivo de una nueva diana terapéutica y de la estrategia multidiana para el tratamiento de estas condiciones
[spa] La enfermedad de Alzheimer (EA) es el tipo de demencia más común. En los últimos años su prevalencia se ha incrementado preocupantemente, considerándose la epidemia del siglo XXI. Hasta ahora solo se han conseguido ...
Efectes metabòlics, vasculars i cognitius del consum de sucres simples en rates femella
En les últimes dècades, l’increment del consum de sucres, especialment de fructosa, s’ha associat al desenvolupament de la obesitat i d’alteracions metabòliques com ara diabetis, hipertensió i malalties cardiovasculars. ...
Efecto del síndrome metabólico provocado por una dieta rica en grasa en ratones APPswe/PS1dE9, modelo experimental de la enfermedad de Alzheimer, y posibles terapias farmacológicas
La enfermedad de Alzheimer (EA) es el tipo de demencia progresiva más común. En base al incremento de la prevalencia esperada, es considera la epidemia del siglo XXI. En consecuencia, surge una gran necesidad de encontrar ...
Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis
The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. Following the ...
Estudio de los efectos en el neurodesarrollo de productos a base de plantas (PBPs) consumidos por la población gestante y lactante usando el modelo del pez cebra
[spa] A nivel mundial, el uso de productos a base de plantas (PBPs) entre las mujeres durante el embarazo y la lactancia se estima en un 60% en los países occidentales y 76% en países orientales, pero no hay datos sobre ...
Exploring novel target combinations for treating neurodegenerative diseases
[eng] Neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), affect millions of people worldwide and share common multifactorial characteristics, including neuroinflammation, oxidative ...
From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors
Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide ...
G9a, a histone lysine methylatransferase, as a potential target for Alzheimer’s disease
[eng] Alzheimer’s disease (AD) is the most common cause of dementia that currently lacks effective pharmacological treatment. Identifying new targets to halt disease progression is a pressing need. In most cases, AD has a ...
GDF15, a novel regulator of the AMPK-mediated antidiabetic actions of PPARβ/δ and metformin
Type 2 diabetes (T2D) is a multifactorial disease that comprises metabolic defects in multiple organs. Several studies have shown that the presence of a chronic low-state inflammatory process induces the development of ...
