Departament de Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 21-40 of 55
Modificaciones en la herencia epigenética inducidas por la dieta grasa revertidas por el resveratrol en el modelo murino SAMP8
Factores ambientales como el ejercicio, el estrés o la dieta contribuyen a la patogénesis de enfermedades asociadas al deterioro cognitivo y al envejecimiento, modulando mecanismos de expresión génica que son susceptibles ...
GDF15, a novel regulator of the AMPK-mediated antidiabetic actions of PPARβ/δ and metformin
Type 2 diabetes (T2D) is a multifactorial disease that comprises metabolic defects in multiple organs. Several studies have shown that the presence of a chronic low-state inflammatory process induces the development of ...
From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors
Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide ...
Stress influence in neurodegeneration. Unravelling the mechanisms underlying stress response in brain ageing by 11ß-HSD1 inhibition
The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have ...
Síntesis formal enantioselectiva del macrólido calispongiolida
La calispongiolida es un macrólido aislado en el año 2013 a partir de un extracto metanólico de la esponja Callyspongia sp. recogida en la costa de Indonesia. Este producto natural posee una potente actividad citotóxica y ...
Design and synthesis of heterocyclic compounds potentially antitumor by enzymatic inhibition
This doctoral thesis is focused on the investigation and development of new compounds directed to different cancer and tropical diseases targets. Drug resistance, as well in cancer as in tropical diseases, is a hurdle which ...
Palladium, ruthenium and iron in intramolecular transition metal-catalyzed carbene functionalization reactions of amino-tethered α-diazoesters
Transition metal-catalyzed intramolecular C–H insertions of diazo compounds represent one of the most elegant and versatile methods in organic synthesis for the construction of carbocyclic and heterocyclic frameworks. ...
Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones
Drugs of abuse represent a global problem not only at a health level, but also at a social and economic extent. Recently, a tidal wave of new emerging psychoactive substances has completely modified the illicit drug market, ...
Multitarget strategies in search of novel drug candidates against Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia and one of the most important health-care problems in the world, due to its high prevalence and unaffordable personal and economic impact. Moreover, current ...
Multi-functionalization of micro- and nanoparticles for cancer theranostics
This thesis has its main focus on developing multi-functional nanomaterials, that we called nano- and microtools through two different approaches, top-down to provide support and bottom up to give functionality to prepare ...
Una estrategia unificada para la síntesis enantioselectiva de los alcaloides del grupo de las madangaminas
El presente trabajo se centra en los alcaloides del grupo de las madangaminas, un pequeño grupo de alcaloides diaminopentacíclicos, aislados de esponjas marinas pertenecientes al orden Haplosclerida y derivados biogenéticamente ...
Isocyanide as a key functional group for the synthesis of biologically active compounds
The distinctive reactivity of isocyanides has been recognised as an advantageous characteristic for the formation of heterocyclic compounds. In the present manuscript new synthetic possibilities are explored involving the ...
Palladium in azaheterocyclic synthesis: α-arylation of sulfones, domino processes and C-H carbene insertion reactions
Among transition metals used in organic chemistry, palladium has greatly contributed to the development of modern organic synthesis. This thesis is focused on the development of novel and efficient methodologies for the ...
Efecto del síndrome metabólico provocado por una dieta rica en grasa en ratones APPswe/PS1dE9, modelo experimental de la enfermedad de Alzheimer, y posibles terapias farmacológicas
La enfermedad de Alzheimer (EA) es el tipo de demencia progresiva más común. En base al incremento de la prevalencia esperada, es considera la epidemia del siglo XXI. En consecuencia, surge una gran necesidad de encontrar ...
Novel potential determinants in endoplasmic reticulum stress, inflammation and insulin resistance: Apo CIII and sAPPβ
Diabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the ...
Mecanismos implicados en la neurodegeneración inducida por dieta grasa en modelos de senescencia
La población mundial está envejeciendo, la mayoría de países del mundo están experimentando un aumento en el número y la proporción de personas mayores. Los últimos datos publicados de la ONU en 2017 informan que se espera ...
Common scaffolds for the enantioselective synthesis of marine, plant, and amphibian cis-decahydroquinoline alkaloids
Chiral amino alcohol derived lactams are a valuable scaffold for the enantioselective synthesis of alkaloids. In the present thesis the potential of this methodology was expanded and to demonstrate the synthetic utility ...
Development of New Multicomponent Processes based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications
1. It was observed that the interaction of imines and isocyanides in the presence of a Lewis acid can lead to a variety of scaffolds including α-aminoamides, α-aminoamidines, indoles and diiminoazetidines. The reaction ...
Novel ᴫ-Functional Components of Micro- and Nanoparticles for Nanomedicine
The present thesis is included in the area of Nanomedicine and supramolecular chemistry, focused on the design and preparation of different nano and microtools for delivery, therapy and sensing. Initially, the synthesis ...
Novel multi-target directed ligands as drug candidates against Alzheimer’s disease
Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...
