Now showing items 61-80 of 107
Elias Miró, Maria (Date of defense: 2014-01-24)
La presente tesis se enmarca dentro del estudio de la lesión por isquemia-reperfusión (I/R), y sus efectos sobre la regeneración, en hígados esteatósicos y no esteatósicos. Uno de los principales riesgos en la cirugía ...
Bernadó Morales, Cristina (Date of defense: 2015-04-23)
In response to oncogenic stresses cells activate two different tumor suppressor mechanisms: Oncogene-induced senescence (OIS), a terminal cell proliferation arrest, or oncogene-induced apoptosis (OIA), which leads to cell ...
Álamo Vargas, Patricia (Date of defense: 2012-12-13)
Los modelos de cáncer colorrectal (CCR) generados mediante inyección ortotópica de líneas celulares de CCR humano, cultivadas extensamente in vitro, tienen escasa eficiencia metastásica. Únicamente un porcentaje bajo de ...
Latil de Ros, Derek (Date of defense: 2017-03-07)
Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the ...
Hosseini, Seyed Ali (Date of defense: 2015-05-08)
A complete understanding of complex formation between proteins and ligands, a crucial matter for pharmacology and, more in general, in biomedicine, requires a detailed knowledge of their static and dynamic atomic interactions. ...
Terribas Pérez, Ernest (Date of defense: 2016-01-20)
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...
Sala Hojman, Ada (Date of defense: 2016-07-15)
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Castel Morales, Pau (Date of defense: 2016-05-09)
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
Abd El Rahim Metwally, Galal Yahya (Date of defense: 2016-01-13)
Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream ...
Torroba Balmori, Mª Blanca (Date of defense: 2016-11-11)
Development of the spinal cord involves coordination between exposure to localized extracellular signals and controlled activation of intracellular signaling pathways. This way, neuroepithelial cells firstly proliferate ...
Espinosa Ferrer, Sonia (Date of defense: 2015-07-20)
Las enfermedades cardiovasculares son la primera causa de muerte en todo el mundo y representan uno de los desafíos primordiales en la investigación biomédica. La aterosclerosis es causante de la mayoría de las enfermedades ...
Cingolani, Francesca (Date of defense: 2015-07-10)
Sphingolipids (SLs), essential components of cell membranes, are bioactive molecules involved in the regulation of a variety of cellular processes. Ceramide and sphingosine generally mediate anti-proliferative stimuli, ...
Pantazi, Eirini (Date of defense: 2015-07-06)
Ischemia-reperfusion injury (IRI) is an inevitable situation in clinical settings such as liver transplantation and hepatic resection. It develops when blood flow is interrupted for a long period of time (ischemia) and ...
Bassani, Nicklas (Date of defense: 2017-12-15)
Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these agents mainly serve ...
Andrés Benito, Pol (Date of defense: 2019-12-17)
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically distinct neurodegenerative diseases that are connected by genetic and pathological overlap. ALS patients present with muscle ...
Avó Freixo, Francisco Duque Projecto (Date of defense: 2016-10-20)
The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such as their stability, ...
Delgado Cirilo, Antonio (Date of defense: 1986-01-01)
Las modificaciones moleculares que constituyen el objetivo de la presente Tesis pretenden aportar nuevos datos que permitan un más amplio conocimiento de los requisitos estructurales y estereoquímicos necesarios tanto ...
Funtikova, Anna N. (Date of defense: 2015-11-30)
Cardiovascular diseases (CVD) are the principal cause of mortality worldwide. Lifestyle plays a crucial role in preventing the development of CVD, and one of its key elements is diet, which directly affects cardiometabolic ...
Jiménez Castro, Mónica B. (Date of defense: 2014-03-04)
In this thesis the role of cyclic AMP , the endoplasmic reticulum stress and adipocytokines such as adiponectin, resistin and visfatin injury in I/R in steatotic liver grafts and non- steatotic undergoing transplantation ...
Cal Pérez-Quevedo, Roi (Date of defense: 2013-04-19)
Las alteraciones del metabolismo lipídico causadas por la isquemia miocárdica tienen profundos efectos en el estado fisiológico del corazón. En el corazón isquémico, la hipoxia incrementa la formación de vacuolas lipídicas ...