Universitat de Girona
Now showing items 41-60 of 111
Mammalian spermatozoa acquire functionality during epididymal maturation and ability to penetrate and fertilize the oocyte during capacitation. Sperm quality results indicated that both epididymal maturation and ejaculation ...
Ribonucleases are promising candidates for use in anticancer therapy. There are different ways to endow an RNase with antitumor properties. Targeting the enzyme to the cell nucleus is a potential approach. PE5 is a variant ...
Serum levels of several molecules associated to pancreatic adenocarcinoma (PDAC) pathophysiology are evaluated in this work, in order to determine their diagnostic value, distinguishing between PDAC patients and healthy ...
Chromosome abnormalities are one of the most important causes of congenital disorders. The main goal of this research is to give a broad view of the use and evolution of prenatal and postnatal cytogenetic diagnosis in ...
Colorectal Cancer is the main type of cancer in Spain. Up to 90% of the cases are sporadic in nature and its aetiology is still unclear. It is supposed to be a multi-factorial disease, where factors play an important role ...
The conservation of species relies on a deep knowledge of biology of the species concerned, as well as on the identification of reproductively isolated units, which are genetically different from one other (genetic stocks). ...
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
The overuse of antibiotics has led to the selection of resistant strains. This thesis investigated the occurrence of antibiotic resistance genes (ARGs) in aquatic microbial communities influenced by anthropogenic activities. ...
This thesis is about challenges that currently concern in vitro production (IVP), sex determination procedures and sex-related survival of in vitro-produced porcine embryos. Specifically, the current thesis develops a new ...
In the present Thesis, we observed that vitrifying-warming porcine embryos had detrimental effects. Indeed, vitrification and warming were seen to reduce developmental ability and quality of in vitro produced porcine ...
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these limitations through ...
Les inteïnes són dominis proteics que mitjançant un procés de tall i unió s’autoescindeixen de la cadena polipeptídica precursora i catalitzen la unió de les seqüències flanquejants (exteïnes) mitjançant un enllaç peptídic. ...
Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and ...
The results obtained in this thesis indicate that StNAC103 promoter activity is induced in tissues undergoing suberin synthesis. Moreover StNAC103 transcript accumulation is concomitant to that of CYP86A33 and takes place ...
El disseny i la producció de zimògens de ribonucleases que puguin ser específicament activats per la proteasa d’un patogen, constitueix un enginyós mecanisme per controlar la seva activitat enzimàtica i, conseqüentment, ...
Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics de les cèl•lules mare ...
Nowadays, the combination of the autotrophic nitrification together with heterotrophic denitrification is the most common process for N-removal in the WWTPs. However, when the C:N ratio is low, this two-step process does ...
Mosquitofish is a small, voracious, highly fecund freshwater fish species originated from northeaster America, that was introduced worldwide to control mosquito populations. In this thesis we have studied the genetics of ...
The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that ...
