García Galindo, Glòria (Date of defense: 2016-07-19)
Les ribonucleases són enzims que presenten citotoxicitat selectiva per a cèl·lules tumorals. S'ha proposat l’ús de ribonucleases dirigides a nucli (ND-RNases) com a fàrmacs antitumorals. En aquest treball ...
Font i Sadurní, Josep (Date of defense: 2006-06-02)
Utilitzant temperatura i pressió com a agents desnaturalitzants s'ha explorat la contribució a l'estabilitat de diferents residus del principal nucli hidrofòbic de la RNasa A. Aquests resutats suggereixen ...
Panosa Roqueta, Clara (Date of defense: 2015-12-14)
The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying ...
Blanco Aparicio, Carmen (Date of defense: 1998-07-17)
In this work we report that potato carboxypeptidase inhibitor suppresses the growth of several human and mouse pancreatic adenocarcinoma cell lines. The inhibitor also reduces the growth of solid tumors ...
Comajoan von Arend, Pau (Date of defense: 2019-12-18)
Recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for the treatment of acute ischaemic stroke. However, the application of this therapy is limited to <5-7% of ...
Camprubí Font, Carla (Date of defense: 2019-07-26)
The adherent-invasive Escherichia coli (AIEC) pathotype could play a role in the course of Crohn’s disease. This is characterized by its capacity to adhere to and to invade intestinal epithelial cells ...
Coll Constans, M. Gràcia (Date of defense: 2000-03-31)
Bovine pancreatic ribonuclease A (RNase A, EC 3.1.27.5) has been extensively studied from the structural, mechanistic and functional points of view. Within the protein folding context, it ...
Bravo Bonilla, Marlon Rolando (Date of defense: 2022-06-16)
Cancer is the leading cause of death due to non-communicable diseases worldwide. Despite the advances in the development of new antitumor drugs, there are still problems such as the resistance that tumor ...
Díaz Roldán, Ferran (Date of defense: 2023-07-03)
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of ...
Viñolas Vergés, Estel (Date of defense: 2023-07-27)
Male fertilising capacity has traditionally been predicted by the assessment of sperm concentration, motility and morphology. During the last few decades, however, research has been particularly focused ...