Universitat de Barcelona
Now showing items 322-341 of 457
Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with more than 90% of ...
Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, where pro-apoptotic ...
STUDY I HYPOTHESIS Genetic alterations have already been recognized as major etiological factors for ASD and ID, of which RTT is an example. In addition to the contribution of polymorphic variants that confer low or ...
Colorectal cancer (CRC) is one of the most frequent malignancies worldwide and it is considered an important healthcare problem. Moreover, colorectal carcinogenesis is a long stepwise process through a known precursor, the ...
Transforming growth factor-beta (TGF-β) is an important growth suppressor in hepatocytes, inhibiting proliferation and inducing cell death. However, it also plays a role in other processes such as epithelial-to-mesenchymal ...
Malaria is responsible of almost half a million deaths every year. Currently, campaigns for the control and elimination of malaria are implemented in malaria endemic areas. However, drug resistance is one of the major ...
Antiretroviral therapy has dramatically reduced morbidity and mortality associated with HIV-1 infection and converted AIDS into a manageable chronic disease. During the past 15 years, antiretroviral drugs have become less ...
La sortida de mitosis comprèn tots els processos de la mitosis que van des de la segregació de les cromàtides germanes a l’obtenció de dues cèl·lules filles genèticament idèntiques. A nivell molecular, les cèl·lules inicien ...
INTRODUCCIÓN: la ultrasonografía endoscópica (USE) y la punción aspirativa con aguja fina guiada por USE (USE-PAAF) han demostrado su utilidad en gran número de situaciones clínicas durante los últimos 20 años. El hecho ...
El cáncer de páncreas es la cuarta causa de muerte por cáncer en los países industrializados. En 2030, las predicciones señalan que puede pasar a ser la segunda. Pese a la relativa baja incidencia de este tipo de cáncer, ...
La infección por el virus de la inmunodeficiencia humana (VIH) continúa siendo un problema importante de salud pública mundial. En 2017 aproximadamente 36,9 millones de personas eran portadoras del VIH (incluidos 1,8 ...
La infección por VHC constituye un problema mundial de primer orden, siendo la primera causa de trasplante hepático en todo el mundo. Se trata de un patógeno muy adaptado a humanos, probablemente durante miles de años en ...
En la última década, frente al fracaso de los tratamientos farmacológicos para detener el proceso patológico de la enfermedad de Alzheimer, la fase preclínica se ha convertido en un importante foco de investigación, puesto ...
La presente tesis incluye dos trabajos: PRIMER TRABAJO High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy Cardesa-Salzmann ...
El tractament de quimioteràpia associada a fàrmacs anti-EGFR representa un estàndard de tractament oncològic per a un subgrup de pacients amb Càncer colorectal metastàtic (CCRm). Malgrat això, no tots el pacients que reben ...
BACKGROUND: Early and appropriate antibiotic administration has been shown to be the most effective intervention for reducing mortality in critically ill patients with septic shock and multiple organ dysfunction syndrome ...
Orthopaedic device-related infections represent a health care problem of first magnitude due to the increasing incidence, complexity of management, and elevated cost. These device related infections have etio-pathogenic ...
A lo largo de esta tesis se han utilizado las oscilaciones lentas (SO), que emergen durante el sueño de onda lenta y bajo el efecto de ciertos tipos de anestesia, como paradigma para detectar alteraciones funcionales en ...
The present Thesis addressed different questions concerning spontaneous oscillatory activity in the cerebral cortex, including functional comparative studies, studies of mechanisms generating this activity and the evaluation ...
Osteoarticular infections are frequent in the clinical practice and have a high impact on patients and health systems. These infections may be associated with concomitant bacteremia and a characteristic feature is the ...
