Facultat de Farmàcia i Ciències de l'Alimentació: Enviaments recents
Ara mostrant els elements 1-20 de 349
La disfàgia orofaríngia a la malaltia de la neurona motora. Prevalença, diagnòstic i dietoteràpia
[cat] Introducció: la malaltia de la neurona motora (MND) cursa amb debilitat progressiva de la musculatura i acaba conduint a la mort del pacient en 3-5 anys. La supervivència augmenta fins a 10 anys en alguns fenotips. ...
Advancing antileishmanial treatments through innovative nanotechnology in vitro approaches and characterization of novel therapeutic compounds
[eng] Leishmaniasis is a vector-borne disease, caused by the parasite Leishmania spp. and transmitted by sand flies of the genus Phlebotomus or Lutzomyia. There are over 12 million people infected worldwide and around one ...
Protección de hígados patológicos frente a la lesión y al fallo en la regeneración asociado a la cirugía hepática
[spa] El hígado es un órgano vital para el organismo por la multitud de funciones que desarrolla. Cuando se compromete su actividad, puede ser necesario recurrir a una cirugía mayor hepática. La resección hepática, asociada ...
Development of a novel CPT1 enzymatic assay for drug screening. Synthesis and evaluation of UB006 derivatives and flavonoids’ effect on lipid
[eng] Lipid metabolism (biosynthesis, storage, and mobilization of lipids within an organism) is a very important aspect of energy homeostasis and plays an essential. Obesity is a complex multifactorial disease characterized ...
Design and Evaluation of Enzyme-Powered Nanobots for Crossing Biological Barriers and Treating Cancer
[eng] The field of nanomedicine has garnered increasing clinical interest over the past few decades, leading to the approval of numerous products, particularly in oncology. This is due to their ability to encapsulate and ...
Investigating abdominal aortic aneurysm mechanisms: searching for new therapeutic targets to restrain inflammation and vascular remodelling
[eng] Abdominal aortic aneurysm (AAA) is a prevalent vascular degenerative disease defined as a focal and permanent dilation of the aorta at the abdominal level. The progressive weakening of the aortic wall can ultimately ...
Effect of different types of Mediterranean diet, types and quality of breakfasts, and sourdough bread on cardiometabolic risk in a population with high cardiovascular risk
[eng] Cardiovascular diseases are a major public health concern in Spain, where they are the leading cause of death. Lifestyle interventions, and diet in particular, are useful strategies to prevent cardiovascular disease ...
Pegilación y liofilización de nanopartículas sólidas lipídicas con colesteril oleato como vectores de ácidos nucleicos
[spa] Las nanopartículas catiónicas sólidas lipídicas (cSLN) han surgido como una herramienta prometedora en terapias genéticas y de ARN. Esta investigación se enfocó en mejorar la formulación existente de SLNs con colesteril ...
Role of HIVEP2 in drug-tolerant persister cancer cells and tumor recurrence
[eng] Colorectal cancer (CRC) is a leading cause of death worldwide and tumor recurrence is a frequent complication that arises from minimal residual disease (MRD). Patients can relapse months or even years after an apparent ...
Mecanismos de señalización en el trasplante hepático de donantes con criterio extendido
[spa] En la práctica clínica, el trasplante de hígado supone una de las pocas soluciones a enfermedades hepáticas en estado terminal. Multitud de personas fallecen esperando un injerto hepático debido a la escasez de ...
Role of conjugated sterols homeostasis in plant development and stress response
[eng] Phytosterols are a family of triterpenoid compounds that occur in free form (FS) or conjugated as steryl esters (SE), steryl glycosides (SG) and acylated steryl glycosides (ASG). Free sterols and their glycosylated ...
CPEB4 regulation of vasculogenic mimicry in liver cancer: mechanisms and therapeutic implications
[eng] BACKGROUND: Hepatocellular carcinoma (HCC) poses a significant clinical challenge due to its complex vascular abnormalities and the regulatory mechanisms underlying tumor progression. Vasculogenic mimicry (VM), a ...
Effects of Mediterranean Diet on Cardiometabolic Biomarkers in Randomized Clinical Trials: Molecular Mechanisms
[eng] Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. This global burden continues to rise due to aging populations, unhealthy diets, sedentary lifestyles, and increasing rates of obesity and ...
Explorant tres segles de col·leccions de l’Institut Botànic de Barcelona: fonts de coneixement per a diversos aspectes de la botànica i de la història de la ciència
[cat] En aquesta tesi doctoral, mitjançant l’estudi dels herbaris històrics i dels materials d’arxiu de l’Institut Botànic de Barcelona (IBB), s’amplia el coneixement sobre alguns botànics vinculats a aquestes colꞏleccions ...
Nanopartículas lipídicas de Apigenina y Melatonina en farmacoterapia oncológica y ocular
[spa] Los sistemas nanoestructurados lipídicos (NLC) han surgido como una herramienta prometedora en la nanomedicina, ofreciendo una gran versatilidad para la administración dirigida de fármacos. Su biocompatibilidad, ...
The impact of soluble epoxide hydrolase inhibition and epoxyeicosatrienoic acids on early-life microglia activation and neuroinflammatory responses in the brain
[eng] Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive decline and is the most common cause of dementia worldwide. AD has a complex multifactorial aetiology influenced by ...
BODIPY-functionalized nanostructured materials for intracellular glutathione sensing and mitochondria bioimaging
[eng] In the present thesis, molecular probes and functionalized nanostructured materials were prepared for the detection and quantification of intracellular glutathione (GSH), as well as mitochondria bioimaging. For this ...
Impact of dietary inflammatory potential and (poly)phenols on cardiometabolic health
[eng] Obesity and cardiometabolic diseases (CMD) represent a growing health problem worldwide. The prevalence of CMD and metabolic syndrome (MetS) is increasing in adults and children. The early development of these ...
Innovación en la detección de Legionella y en el cultivo de bacterias exigentes
[spa] La legionelosis o enfermedad del legionario es una enfermedad infecciosa provocada por Legionella, una bacteria gramnegativa aeróbica estricta y un patógeno intracelular facultativo. Se transmite en humanos principalmente ...
Optimización del diagnóstico parasitológico de la leishmaniosis tegumentaria y caracterización de especie/s de Leishmania causantes del cuadro clínico en Cochabamba (Bolivia)
[spa] En Bolivia, la leishmaniosis tegumentaria (LT) abarca siete de los nueve departamentos, siendo uno de los países que presenta un mayor número de casos de leishmaniosis mucosa (LM) o leishmaniosis mucocutánea (LMC). ...
