Facultat de Medicina i Ciències de la Salut: Envíos recientes
Mostrando ítems 61-80 de 547
Developing exhaustion-resistant CAR-T cells for the treatment of solid tumors
[eng] Adoptive cell therapy using Chimeric Antigen Receptor (CAR)-T cells has demonstrated remarkable results in patients with certain types of cancer. CARs are synthetic receptors designed to redirect T cells against ...
Limitació de la plasticitat metabòlica per incrementar l’eficàcia dels fàrmacs inductors de dany a l’ADN en càncer
[cat] Les alteracions en la reparació de l'ADN són clau en el procés tumorogènic. Així, la reparació dels trencaments de doble cadena (DSB) és una tasca fonamental en la preservació de la integritat dels cromosomes. La ...
Evaluating differentiated service delivery across the HIV care continuum: from testing to treatment monitoring in Mozambique
[eng] INTRODUCTION: Eastern and southern Africa (ESA), which accounts for 53% of all people living with HIV (PLHIV) worldwide, has yet to achieve the UNAIDS 95-95-95 targets for 2025: 95% of PLHIV know their status, 95% ...
Lipoproteínas, inflamación y antioxidantes dietéticos en la enfermedad cardiovascular
[spa] INTRODUCCIÓN: Las enfermedades cardiovasculares (ECV) son la principal causa de mortalidad en todo el mundo. La cardiopatía isquémica, que representa aproximadamente un tercio de los casos de ECV, se origina por el ...
Identificación de predictores de arritmias cardíacas y muerte súbita en pacientes pediátricos afectos de enfermedades neuromusculares
[spa] INTRODUCCIÓN: Las enfermedades neuromusculares son enfermedades raras de base genética y que pueden manifestarse desde edades muy tempranas y pudiendo tener manifestación cardíaca. Esta afectación cardíaca, cada vez ...
Longitudinal multimodal data analysis and innovative digital solutions for studying trajectories of brain health
[eng] INTRODUCTION: Aging is a process characterized by significant individual variability, influenced by multiple factors that determine whether it will be healthy—marked by good quality of life and optimal physical, ...
Análisis de la autogestión del cuidado de la diabetes tipo 1 en población infantil y adolescente
[spa] INTRODUCCIÓN: La diabetes tipo 1 (DT1) es una enfermedad autoinmune que destruye las células beta del páncreas, las cuales producen insulina. La insulina es una hormona vital cuya función principal es facilitar ...
Inhibició del catabolisme de la lisina mitjançant teràpia gènica com a aproximació terapèutica per a l’Acidúria Glutàrica tipus 1
[cat] L'acidúria glutàrica tipus 1 (AG1) és una malaltia metabòlica hereditària causada per la deficiència enzimàtica de glutaril-CoA deshidrogenasa (GCDH), una proteïna implicada en el catabolisme de la lisina, el triptòfan ...
Inhibition of the PI3K/Akt pathway as a therapeutic strategy for pediatric-type diffuse high-grade gliomas
[eng] This thesis aims to contribute to the field of therapy development in pHGG. These deadly cancers infiltrate structures such as the brainstem, cerebellum, thalamus and spinal cord, rendering surgery unfeasible. All ...
Genetic and Epigenetic Contributions to Psychotic Disorders: From Early Vulnerability to Clinical Onset in Precision Psychiatry
[eng] INTRODUCTION: Psychotic disorders are complex in their etiology, as they involve genetic, epigenetic and environmental factors. This complexity translates into a great clinical heterogeneity, with different stages ...
Deciphering tumorsphere biology in ovarian cancer
[eng] Epithelial ovarian cancer (EOC) is the fifth-leading cause of cancer death among women and the most lethal gynecological malignancy. High-grade serous ovarian carcinoma (HGSOC) is the most prevalent and aggressive ...
Efectividad de la acupuntura como estrategia complementaria previa a la inducción programada del parto
[spa] La inducción del parto es un procedimiento habitual en el embarazo, consiste en provocar el inicio de las contracciones de parto, bien por métodos mecánicos o farmacológicos, antes de que éste se inicie de forma ...
Transcriptome analysis and functional characterization of Plasmodium vivax spleen and bone marrow dependent genes and the role of the extracellular vesicles in cryptic niche formation
[eng] INTRODUCTION: Plasmodium vivax is the most widespread malaria parasite, with 2.8 billion people at risk across regions from Southeast Asia to the Americas. In 2022 alone, approximately 6.9 million clinical cases ...
New biomarkers of cardiometabolic risk: Hypothalamus-pituitary-adrenal axis and subclinical atherosclerosis. From type 1 diabetes to chronic kidney disease
[eng] INTRODUCTION: Type 1 diabetes (T1D) and chronic kidney disease (CKD) are populations with high cardiovascular risk and mortality despite recent improvements in healthcare. New strategies are needed to tackle ...
Deciphering the trajectory of iPSC-derived hepatic stellate cells in physiology and disease
[eng] Hepatic stellate cells (HSCs) are mainly responsible for liver fibrosis, a common feature in all liver diseases, regardless of their etiology, and which currently has no treatment. In addition, fibrosis is directly ...
Generación de una fuente de linfocitos T alogénicos para su uso en terapia CAR-T contra enfermedades oncológicas e infecciosas
[spa] El uso de linfocitos T de donantes para la inmunoterapia celular tiene en el rechazo por alogenicidad la principal limitación. En este sentido mientras que la reducción en la expresión de las moléculas del complejo ...
Advancing in Endometrial Cancer Prevention: Exploring the Role of Circadian Disruption Factors and the Sensitivity of Cervicovaginal Cytology for its Detection
[eng] INTRODUCTION: Endometrial cancer (EC) is the most common gynecological tumor in developed countries, with an increasing incidence due to population aging and growing obesity. This cancer is estrogen-dependent, so ...
Understanding the immunogenicity of RTS,S/AS0 vaccination in African children: antigen glycosylation, booster dose and off-target antibody responses
[eng] INTRODUCTION: Malaria, caused by Plasmodium falciparum, remains a major public health concern, especially in children under 5 years of age in sub-Saharan Africa. RTS,S/AS01E is the first of two malaria vaccines ...
Role of Sirtuins in haematopoiesis and leukaemia
[eng] Haematopoiesis is the process by which haematopoietic stem cells replenish all blood cell types, including myeloid cells and lymphocytes, throughout life in mammals. In particular, B lymphocytes or B-cells are the ...
Elucidating variable disease severity of X-linked adrenoleukodystrophy through multiomics and metagenomics of gut microbiome
[eng] X-linked adrenoleukodystrophy (X-ALD) is a rare and devastating neurodegenerative disorder characterized by inflammatory demyelination of the brain and/or axonal degeneration in the spinal cord. This arises from a ...
