Universitat Pompeu Fabra
Now showing items 1053-1072 of 1297
Background: Previous studies have focused on analysing specific labour market situations and their relationship with sickness absence (SA). However, little is known about the relationship between mobility between different ...
p38α (encoded by MAPK14) is a major regulator of cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates various substrates both in the cytoplasm and nucleus, ...
Memory is a physiological brain function crucial for adaptive behaviour of individuals. Memory alterations are described as impairments in the processes by which memory is perceived, encoded, consolidated, retrieved, or ...
We have identified a novel Cyclin, called Cyclin O, which is able to bind and activate Cdk2 in response to intrinsic apoptotic stimuli. We have focused on the study of Cyclin Oα and Cyclin Oβ, alternatively spliced ...
The infection of gastric mucosa by Helicobacter pylori is a key step in the initiation and evolution to gastric adenocarcinomas. Prolonged infection promotes the infiltration of inflammatory cells and subsequent increased ...
Chromatin organization and gene expression are interdependent. Previously, our group showed that nucleosomes form groups, termed clutches, whose size correlates with cell state. In this thesis, we carried out 3D, 2-color ...
Los sinusoides del bazo humano promueven la lenta percolación de la sangre, favoreciendo la captura de antígeno por los fagocitos y linfocitos del sistema inmune local. Estratégicamente posicionadas delimitando los ...
La adicción es un trastorno crónico de la conducta caracterizado por la búsqueda y el consumo compulsivos de la droga, la pérdida de control para limitar dicho consumo, a aparición de un estado emocional negativo cuando ...
Els treballs realitzats en aquesta tesi tenen com objectius l'aplicació de la sistemàtica molecular i la filogeografia per resoldre relacions filogenètiques, clarificar la taxonomia i descriure la història de les poblacions ...
Muscle aging, in particular, is characterized by the reduction of tissue mass and function, which are particularly prominent in geriatric individuals undergoing sarcopenia. The age-associated muscle wasting is also associated ...
This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. ...
The Snail1 transcriptional repressor is a key factor responsible in triggering epithelial to mesenchymal transition. Although Snail1 is widely expressed in early development, it is limited in adult animals to a subset of ...
Carcinomas initiate their invasion hijacking the innate plasticity of both epithelial cells and mesenchymal stromal cells in a reciprocal way. Chemical and mechanical dialogue between stromal fibroblasts and carcinoma cells ...
Snail1 transcription factor is the key inducer of epithelial-to-mesenchymal transition (EMT). Here, we describe a novel role for Snail1 on the regulation of telomere integrity and transcription as well as telomerase ...
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that the function of ...
El sobrepeso y la obesidad infantojuvenil es uno de los principales problemas de salud pública en el siglo XXI debido principalmente a su elevada prevalencia a nivel mundial y al alto impacto que puede tener sobre la ...
Introduction Neuropsychological development is a genetically guided process which is continuously modified by socio-environmental factors. This thesis aimed to study the main socio-environmental determinants of ...
The present thesis aims to give a critical overview of the health care and health inequalities for the Mozambican case. The thesis is divided into four articles, two of them are quantitative articles analysing data from ...
Introduction The influence of the environment, and its interplay with genetics, can account for up to half of the variance of neurodevelopmental disorders. In this thesis we reviewed previous literature on air pollution ...
The general objective of this dissertation was to study the state of sexual and reproductive health of the Spanish population in reproductive age, especially focusing on individual and contextual socioeconomic inequalities. ...
