Programa de Doctorat en Biomedicina: Envíos recientes
Mostrando ítems 21-40 de 1383
Immune evasive mechanisms in breast cancer micrometastasis
In metastasis, the existence of tumor cells overcoming the immune system during early organ seeding is crucial, yet the dynamics of tumor-immune interactions during micrometastasis remain unclear. Identifying the vulnerabilities ...
Unraveling the effects of lymphoma-associated translocations on genome organization and gene regulation
Translocations have largely been associated with tumor development due to oncogene overexpression upon rearrangement. Yet, their precise effects on nuclear architecture and long- range gene regulation remain understudied. ...
Genetic determinants orchestrating transcriptome regulation: nonsense-mediated mRNA decay and allele-specific expression variability in phenotypic diversity
Esta tesis explora la variabilidad de la eficiencia de la degradación del ARN mensajero mediada por mutación terminadora (NMD) y el papel de la expresión específica de alelos (ASE) en la influencia de la variación fenotípica ...
Prediction and characterizacion of enhancer clusters in an induced cell-fate transition model
Large clusters of enhancers often regulate lineage instructive genes. Whether individual enhancers of a cluster cooperate or act independently in regulating gene expression is unknown. Current algorithms that identify such ...
Exploring the role of DYRK1 kinases in cell-autonomous and paracrine activities in pancreatic cancer
Dual-specificity tyrosine-regulated kinases (DYRKs) are a conserved family of protein kinases regulating critical cellular processes. This study investigates the roles of the paralogues DYRK1A and DYRK1B in pancreatic ...
From mitochondrial markers to whole genomes: evolutionary history of African and Arabian horned and sand vipers
This thesis adds new knowledge to the evolutionary history of the genus Cerastes, a group of understudied venomous snakes highly adapted to the arid conditions of North Africa and Arabia. Using several genomic approaches, ...
Development of new insecticide technologies against urban pests based on biomolecules
This industrial thesis provides insights into the development of new insecticide technologies against the cockroach Blattella germanica. We have focused this work on the design of an oral insecticide using RNA interference ...
The impact of amino acid insertions and deletions on protein stability and function
Amino acid insertions and deletions (indels) are common mutational events but there is limited information about their effects on protein stability and function. Whereas substitutions alter amino acid side chains, indels ...
Transport-mediated antimicrobial interactions and resistance mechanism in Escherichia coli
Esta tesis investiga los mecanismos de resistencia a antibióticos y la interacción entre antibióticos y toxinas en Escherichia coli, enfocándose en el paper del canal de membrana TolC en la expulsión de antibióticos e ...
Integrative methods for linking genotype to phenotype: an application to intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is a complex condition influenced by genetics, environment, and lifestyle. Despite advancements in sequencing technologies, challenges remain in understanding the biology of complex ...
Neuromuscular junction dynamics in muscle growth and atrophy
Skeletal muscle exhibits remarkable adaptability in response to physiological and pathological stimuli. This study explores the plasticity of the neuromuscular junction (NMJ), a neural–muscle interface that is crucial for ...
Hypoglycosylation of Piezo1 and Cavα2δ subunit: relevance for neuronal excitability and neurological disorders associated to Phosphomannomutase 2 deficiency (PMM2-CDG)
Els defectes congènits de la glicosilació (CDG) són una família de malalties causades per mutacions en gens involucrats en les vies de la glicosilació. La PMM2-CDG, associada a mutacions en la fosfomanomutasa 2 (PMM2), es ...
From stress to Amyotrophic Lateral Sclerosis mechanobiology: featuring Piezo1 in Motor Neuron Disease
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized in 97% of the cases by the accumulation of TDP-43 in cytoplasmic inclusions. As there is an association between oxidative and mechanical ...
Urban planning and health in all policies: the health impact of green space interventions in cities
The geographical, environmental, and sociocultural characteristics of cities impact residents' health and well-being. Modern cities, while beneficial for people, also face high air and noise pollution, urban heat, and ...
Short and long-term impact of the birth environment on maternal and neonatal health outcomes and childbirth experiences (Birthing Better)
Aquesta tesi doctoral avalua l'impacte i la implementació d'una Unitat Liderada per Llevadores (MLU) en els resultats de salut materna i neonatal, així com la satisfacció materna dins del sistema sanitari espanyol. Utilitzant ...
Neurobiological mechanisms underlying the resilience and vulnerability to developing cannabis and food addiction
The increasing use of cannabis and highly palatable foods in modern society, along with their decreasing risk perception, have raised the prevalence of addiction. However, the neurobiological mechanisms that contribute to ...
Regulation of tumor-infiltrating T lymphocytes by circadian molecular clocks
Circadian rhythms are the natural 24-hour cycles governing physiological processes and play a critical role in regulating immune function. This thesis explores the intricate connections between circadian rhythms and the ...
Inference of selection acting on coding sequences in the human lineage
Selection forces have shaped the current human DNA sequence through evolution. These forces have been consistently changing, in magnitude and direction, across the different evolutionary episodes of the extant human ...
A New in vitro model to study the regulatory functions of β cells in early stages of type1 diabetes
Type 1 Diabetes (T1D) is an autoimmune disease marked by the selective destruction of pancreatic β cells. Early insulitis involves interactions between immune cells and β cells, but the mechanisms leading to β cell death ...
Quantifying cellular behavior during early mammalian development
In this thesis we study cell behaviours such as cellular decision making and self-organization using the developing mouse embryo as the system of study. To be able to extract the most needed cellular dynamics from ...
