Departament de Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 1-20 of 55
Development of Iron-Catalyzed Hydrogen Atom Transfer Driven Cross-Coupling and Cyclization Reactions: Use of Isocyanides, Heterocycles and Tosylhydrazones as Radical Acceptors
[eng] Radical reactions have been proven valuable tools in C-C bond generation because the initial radical can evolve to form additional C-C bonds until the new radical species is trapped. With the careful design of the ...
Nuevas metodologías para la síntesis de espiroindolinas y indoloquinolicidinas. Aplicación a la síntesis de alcaloides indólicos
[spa] Los alcaloides oxindólicos son un grupo de productos naturales caracterizados por la presencia de un sistema espiro[pirrolidina-3,3'-oxindol] y poseen una amplia gama de actividades biológicas. Por esta razón, han ...
Study of new strategies for steatotic liver disease: SIRT1-mediated modulation of VLDLR levels and evaluation of a soluble epoxyde hydrolase-targeted PROTAC
[eng] Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease (CLD). The first stage in the development of MASLD is metabolic dysfunction-associated fatty liver ...
GDF15, AMPK,PPARβ/δ : Estudio de su relación en el control de la glucemia
[spa] La diabetes mellitus tipo 2, una enfermedad multifactorial cuyo principal factor de riesgo es la obesidad, donde se produce la acumulación anormal o excesiva que puede ser dañina para la salud. Esta enfermedad se ...
Reaction space charting of multicomponent processes: a novel approach in organic and biomedical research
[eng] To discover new scaffolds and to streamline the production of novel chemical entities with biological activity is essential for accelerating drug discovery. In this regard, multicomponent reactions (MCRs) offer ...
Developmental toxicity screening in the zebrafish embryo – a metabolomics approach
[eng] Birth defects occur in about 3-6% of human births worldwide (CDC, 2023). To mitigate the risk to the unborn child, the assessment of embryo-fetal developmental toxicity is an integral part of chemical registration ...
Study of the effects of PPAR-β/δ activators in the treatment of MASH
[eng] Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is the most common chronic liver disease around the world, affecting more than 30% of the ...
G9a, a histone lysine methylatransferase, as a potential target for Alzheimer’s disease
[eng] Alzheimer’s disease (AD) is the most common cause of dementia that currently lacks effective pharmacological treatment. Identifying new targets to halt disease progression is a pressing need. In most cases, AD has a ...
Chiral tricyclic lactams as efficient enantiomeric scaffolds for the synthesis of cis-decahydroquinolines substituted on the carbocyclic ring. Total synthesis of Myrioneuron alkaloids
[eng] The Myrioneuron alkaloids constitute a family of natural products found in East and South-East Asia. They feature a cis- or trans-decahydroquinoline (DHQ) as a common unit, attached to an oxazine, a diazine, or a ...
El déficit cognitivo y la enfermedad de Alzheimer en presencia de alteraciones metabólicas: Estudio in vivo de una nueva diana terapéutica y de la estrategia multidiana para el tratamiento de estas condiciones
[spa] La enfermedad de Alzheimer (EA) es el tipo de demencia más común. En los últimos años su prevalencia se ha incrementado preocupantemente, considerándose la epidemia del siglo XXI. Hasta ahora solo se han conseguido ...
Preparació i Avaluació Biològica de Nous Sistemes Heterocíclics Nitrogenats
[cat] Aquest treball està orientat en l’estudi de nous sistemes heterocíclics nitrogenats amb potencial activitat biològica, concretament, en la recerca de nous antitumorals per inhibició enzimàtica. S’ha descrit la ...
Generació de "building blocks" enantiopurs amb un estereocentre quaternari. Aplicació a la síntesi de productes naturals i compostos biològicament actius
[cat] Els alcaloides indòlics monoterpènics del grup leuconolam-leuconoxina-mersicarpina [(–)- mersicarpina, (–)-leuconoxina, (+)-melodinina E] i la (–)-kopsiyunnanina K presenten una interessant activitat biològica juntament ...
Safety and efficacy investigations for new prenatal neuroprotective therapies. Applications in a model of intrauterine growth restriction (IUGR).
[eng] Intrauterine growth restriction (IUGR) is defined as a significant reduction on fetal growth rate, resulting in a birth weight below the 10th percentile for the corresponding gestational age (Sharma et al., 2016). ...
Nous antagonistes del receptor NMDA pel tractament de la malaltia d’Alzheimer. Caracterització farmacològica in vivo
Actualment, el tractament de la malaltia d’Alzheimer (MA) és una necessitat mèdica no coberta, ja que només existeixen tres grups de fàrmacs aprovats que no són suficientment eficaços pel control de la malaltia. La naturalesa ...
Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs
The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...
Phenotyping of sigma-1 receptor knock-out rodents
The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondria-associated endoplasmic reticulum (MAM). It was cloned years ago from different tissues of various species and its structure ...
Validación de dianas farmacológicas para la prevención y el tratamiento de la hipertrigliceridemia y el hígado graso inducidos por el consumo de fructosa líquida y dieta rica en grasa saturada
La enfermedad del hígado graso no alcohólico es una patología sin tratamiento farmacológico específico que posee una alta prevalencia a nivel mundial, cuya etapa inicial se caracteriza por la esteatosis hepática simple. ...
Targeting the I(2) Imidazoline Receptors: the neuroprotective role of selective ligands in Alzheimer’s Disease
The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...
Síntesis de compuestos bioactivos: Ligandos de los receptores imidazolínicos I(2) e inhibidores de la enzima PEPCK
La síntesis de compuestos orgánicos heterocíclicos permite acceder a un amplio arsenal de compuestos con potencial actividad farmacológica. El presente manuscrito se enmarca en el campo de la química farmacéutica, desarrollando ...
Síntesis de alcaloides decahidroquinolínicos de los grupos de la gefirotoxina, flegmarina y cilindricina
Los alcaloides decahidroquinolínicos (DHQs) representan un pequeño grupo de productos naturales aislados mayoritariamente de fuentes animales, ya sean de origen terrestre o de origen marino, y en menor medida de fuentes ...
