Departament de Farmacologia, Toxicologia i Química Terapèutica: Envíos recientes
Mostrando ítems 1-20 de 46
El déficit cognitivo y la enfermedad de Alzheimer en presencia de alteraciones metabólicas: Estudio in vivo de una nueva diana terapéutica y de la estrategia multidiana para el tratamiento de estas condiciones
[spa] La enfermedad de Alzheimer (EA) es el tipo de demencia más común. En los últimos años su prevalencia se ha incrementado preocupantemente, considerándose la epidemia del siglo XXI. Hasta ahora solo se han conseguido ...
Preparació i Avaluació Biològica de Nous Sistemes Heterocíclics Nitrogenats
[cat] Aquest treball està orientat en l’estudi de nous sistemes heterocíclics nitrogenats amb potencial activitat biològica, concretament, en la recerca de nous antitumorals per inhibició enzimàtica. S’ha descrit la ...
Generació de "building blocks" enantiopurs amb un estereocentre quaternari. Aplicació a la síntesi de productes naturals i compostos biològicament actius
[cat] Els alcaloides indòlics monoterpènics del grup leuconolam-leuconoxina-mersicarpina [(–)- mersicarpina, (–)-leuconoxina, (+)-melodinina E] i la (–)-kopsiyunnanina K presenten una interessant activitat biològica juntament ...
Safety and efficacy investigations for new prenatal neuroprotective therapies. Applications in a model of intrauterine growth restriction (IUGR).
[eng] Intrauterine growth restriction (IUGR) is defined as a significant reduction on fetal growth rate, resulting in a birth weight below the 10th percentile for the corresponding gestational age (Sharma et al., 2016). ...
Nous antagonistes del receptor NMDA pel tractament de la malaltia d’Alzheimer. Caracterització farmacològica in vivo
Actualment, el tractament de la malaltia d’Alzheimer (MA) és una necessitat mèdica no coberta, ja que només existeixen tres grups de fàrmacs aprovats que no són suficientment eficaços pel control de la malaltia. La naturalesa ...
Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs
The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...
Phenotyping of sigma-1 receptor knock-out rodents
The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondria-associated endoplasmic reticulum (MAM). It was cloned years ago from different tissues of various species and its structure ...
Validación de dianas farmacológicas para la prevención y el tratamiento de la hipertrigliceridemia y el hígado graso inducidos por el consumo de fructosa líquida y dieta rica en grasa saturada
La enfermedad del hígado graso no alcohólico es una patología sin tratamiento farmacológico específico que posee una alta prevalencia a nivel mundial, cuya etapa inicial se caracteriza por la esteatosis hepática simple. ...
Targeting the I(2) Imidazoline Receptors: the neuroprotective role of selective ligands in Alzheimer’s Disease
The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...
Síntesis de compuestos bioactivos: Ligandos de los receptores imidazolínicos I(2) e inhibidores de la enzima PEPCK
La síntesis de compuestos orgánicos heterocíclicos permite acceder a un amplio arsenal de compuestos con potencial actividad farmacológica. El presente manuscrito se enmarca en el campo de la química farmacéutica, desarrollando ...
Síntesis de alcaloides decahidroquinolínicos de los grupos de la gefirotoxina, flegmarina y cilindricina
Los alcaloides decahidroquinolínicos (DHQs) representan un pequeño grupo de productos naturales aislados mayoritariamente de fuentes animales, ya sean de origen terrestre o de origen marino, y en menor medida de fuentes ...
Modificaciones en la herencia epigenética inducidas por la dieta grasa revertidas por el resveratrol en el modelo murino SAMP8
Factores ambientales como el ejercicio, el estrés o la dieta contribuyen a la patogénesis de enfermedades asociadas al deterioro cognitivo y al envejecimiento, modulando mecanismos de expresión génica que son susceptibles ...
GDF15, a novel regulator of the AMPK-mediated antidiabetic actions of PPARβ/δ and metformin
Type 2 diabetes (T2D) is a multifactorial disease that comprises metabolic defects in multiple organs. Several studies have shown that the presence of a chronic low-state inflammatory process induces the development of ...
From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors
Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide ...
Stress influence in neurodegeneration. Unravelling the mechanisms underlying stress response in brain ageing by 11ß-HSD1 inhibition
The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have ...
Síntesis formal enantioselectiva del macrólido calispongiolida
La calispongiolida es un macrólido aislado en el año 2013 a partir de un extracto metanólico de la esponja Callyspongia sp. recogida en la costa de Indonesia. Este producto natural posee una potente actividad citotóxica y ...
Design and synthesis of heterocyclic compounds potentially antitumor by enzymatic inhibition
This doctoral thesis is focused on the investigation and development of new compounds directed to different cancer and tropical diseases targets. Drug resistance, as well in cancer as in tropical diseases, is a hurdle which ...
Palladium, ruthenium and iron in intramolecular transition metal-catalyzed carbene functionalization reactions of amino-tethered α-diazoesters
Transition metal-catalyzed intramolecular C–H insertions of diazo compounds represent one of the most elegant and versatile methods in organic synthesis for the construction of carbocyclic and heterocyclic frameworks. ...
Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones
Drugs of abuse represent a global problem not only at a health level, but also at a social and economic extent. Recently, a tidal wave of new emerging psychoactive substances has completely modified the illicit drug market, ...
Multitarget strategies in search of novel drug candidates against Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia and one of the most important health-care problems in the world, due to its high prevalence and unaffordable personal and economic impact. Moreover, current ...
