Universitat Pompeu Fabra
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El objetivo principal de esta tesis fue el de realizar una validación y caracterización de las posibles variables que pueden afectar la metodología empleada para identificar las isoformas presentes en algunas de las especies ...
Hemos analizado la variabilidad genética de una zona no codificante autosómica, el pseudogén homólogo al gen de la glucocerebrosidasa (psGBA). <br/>Parte del análisis se ha realizado desde la perspectiva de la genética de ...
Polycomb repressive complex (PRC)1 and 2 are major players in gene regulation, devoted to maintenance of the epigenetic memory of gene silencing. Mouse embryonic stem cells (mESCs) have been extensively exploited as a model ...
En aquest treball de tesis doctoral s'estudia el paper de l'estrès oxidatiu tant a la etiologia com a la patofisiologia del dany vascular associat a la malaltia d'Alzheimer. Es demostra la capacitat de les cèl·lules musculars ...
En aquest estudi s’avaluen algunes de les vies d’exposició principals a diversos contaminants, concretament als compostos organoclorats (OCs) i metalls traça, en infants. La recerca se centra en tres poblacions localitzades ...
El propósito principal de la tesis es contribuir en lo posible a potenciar la vigilancia de las pandemias de las infecciones de transmisión sexual (ITS) y la tuberculosis (TB) en las poblaciones a riesgo de infección a ...
Desplazarse a pie es una actividad física moderada, rutinaria e integrada en la vida diaria que podría convertirse en una herramienta para disminuir la tendencia creciente del sedentarismo de la población. El objetivo ...
Disinfection by-products (DBP) are complex mixtures of toxicants derived from drinking water treatment. Trihalomethanes (THM) and haloacetic acids (HAA) are the most prevalent DBP in chlorinated waters, which are used as ...
This dissertation aims to understand where, why and how scientific knowledge on health inequalities is produced, why and how some places have strong capacity to produce this, and what determines this capacity. It consists ...
Drosophila larvae present unique opportunity for anatomical and functional mapping of their nervous system because of features such as numerical simplicity of neurons its nervous system is composed of, and ability to exhibit ...
The recent discovery that intestinal adenomas are built on a stem cell hierarchy has raised great interest in understanding the signals that maintain tumor stem cells. We unveiled the existence of a transcriptional circuit ...
Las células madre embrionarias (ESCs) derivan de la masa cellular interna de los blastocistos y son capaces de generar las tres capas germinales. Muchos factores controlan la pluripotencia incluyendo la ruta Wnt/β-catenina. ...
The project focuses on cancer and its effects on work trajectories from a life course perspective, both from a qualitative and quantitative approach. Quantitative analyses were based on a retrospective dynamic cohort of ...
X chromosome reactivation in female mouse germ cells is essential for the transmission of one active X chromosome to the progeny. However, despite its key role in development, the mechanistic details and kinetics still ...
Durant la transició Epiteli-Mesènquima (TEM), el factor de transcripció Snail reprimeix la transcripció de l'E-cadherina unint-se a les caixes E presents en el promotor d'aquest gen.<br/>Les cèl·lules que expressen Snail ...
The purpose of this thesis is to introduce and demonstrate several biological processes or phenomena using posterior lateral line system of zebrafish as a model. The first part of this work focuses on the highly dynamic ...
Zinc is an essential trace element with structural, catalytic and signaling roles in our body. At cellular level, zinc homeostasis participates in fundamental functions such as cell proliferation, migration, differentiation ...
Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell proliferation and accumulation of undifferentiated precursors. ZRF1, a ...
Mouse embryonic stem (ES) cells derived from the inner cell mass of the blastocyst can be maintained in culture, under pluripotent conditions, using Serum+LIF medium. However, it has been published that the minimal combination ...
