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Immunotherapeutic strategies for HIV cure: advancements in the characterisation and development of novel immune checkpoints therapeutics for combinatorial HIV1 immune interventions
Human Immunodeficiency Virus Type 1 (HIV-1) remains a global pandemic requiring the development of curative strategies due to the limitations of current antiretroviral treatments (ART). This thesis focuses on the need for ...
A Model of mammary microvasculature: evaluating hormone responsiveness and luminal-like tumor integration
This thesis aims to fill gaps in the research on breast microvasculature by creating a perfusable microvasculature system within a microfluidic platform. For the first time, we co-cultured primary breast endothelial cells ...
Unravelling new targets for pancreatic cancer: Galectin-1 and Parp-2
Pancreatic ductal adenocarcinoma (PDAC) is an unmet medical need characterized by a poor prognosis and high mortality. Until now, no effective therapies have been discovered to achieve disease control. Thus, there is an ...
Engineering TGF-B resistant NK cells for cancer immunotherapy
Natural killer (NK) cells are cytotoxic innate lymphocytes which can recognize tumor targets or virus-infected cells. Adoptive transfer of primary or genetically engineered NK cells for cancer immunotherapy is an attractive ...
Biotechnologies of the future: novel cyanobacteria-based solutions for sustainable industries
This thesis delves into the indispensable role of bacteria across our planet and their profound impact on various industries, encompassing health, agriculture, cosmetics, and materials science. It sheds light on the inherent ...
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